Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion

Morphology-guided transcriptomic analysis of human pancreatic cancer organoids reveals microenvironmental signals that enhance invasion

Pancreatic ductal adenocarcinoma (PDAC) frequently presents with metastasis, but the molecular programs in human PDAC cells that drive invasion are not well understood. Using an experimental pipeline enabling PDAC organoid isolation and collection based on invasive phenotype, we assessed the transcr...

Ful tanımlama

Detaylı Bibliyografya
Asıl Yazarlar: Yea Ji Jeong, Hildur Knutsdottir, Fatemeh Shojaeian, Michael G. Lerner, Maria F. Wissler, Elodie Henriet, Tammy Ng, Shalini Datta, Bernat Navarro-Serer, Peter Chianchiano, Benedict Kinny-Köster, Jacquelyn W. Zimmerman, Genevieve Stein-O’Brien, Matthias M. Gaida, James R. Eshleman, Ming-Tseh Lin, Elana J. Fertig, Andrew J. Ewald, Joel S. Bader, Laura D. Wood
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2023-04-01
Seri Bilgileri:The Journal of Clinical Investigation
Konular:
Gastroenterology
Oncology
Online Erişim:https://doi.org/10.1172/JCI162054

Internet

https://doi.org/10.1172/JCI162054

Benzer Materyaller