Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome
We report a case of prenatal diagnosis of mosaicism for chromosome t (7; 14) with a favorable fetal outcome. Similar chromosomal abnormalities have been observed in patients with hematologic malignancy. Chromosomal microarray analysis (CMA) revealed no genomic imbalance, prenatal ultrasound examinat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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IMR Press
2020-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.4946 |
| _version_ | 1818210680509038592 |
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| author | D. Lu D. Cao Q. Zhao X. Chen |
| author_facet | D. Lu D. Cao Q. Zhao X. Chen |
| author_sort | D. Lu |
| collection | DOAJ |
| description | We report a case of prenatal diagnosis of mosaicism for chromosome t (7; 14) with a favorable fetal outcome. Similar chromosomal abnormalities have been observed in patients with hematologic malignancy. Chromosomal microarray analysis (CMA) revealed no genomic imbalance, prenatal ultrasound examination revealed no intrauterine growth restriction (IUGR) or dysmorphisms in this fetus. Therefore, combination of karyotype analysis, CMA, genetic counseling and prenatal ultrasound will prove a more specific risk evaluation for chromosomal translocation and mosaicism. |
| first_indexed | 2024-12-12T05:20:27Z |
| format | Article |
| id | doaj.art-877a627c638a450fad691c0d2517e3df |
| institution | Directory Open Access Journal |
| issn | 0390-6663 |
| language | English |
| last_indexed | 2024-12-12T05:20:27Z |
| publishDate | 2020-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj.art-877a627c638a450fad691c0d2517e3df2022-12-22T00:36:37ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632020-06-0147342742810.31083/j.ceog.2020.03.4946S0390-6663(20)00281-XPrenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcomeD. Lu0D. Cao1Q. Zhao2X. Chen3Department of Clinical Laboratory, Women and Children’s Hospital of Hubei Province, Wuhan, Hubei, P.R. ChinaDepartment of Obstetrics; Women and Children’s Hospital of Hubei Province, Wuhan, Hubei, P.R. ChinaDepartment of Clinical Laboratory, Dongsheng Area People’s Hospital, Ordos, Inner Mongolia, P.R. ChinaDepartment of Obstetrics; Women and Children’s Hospital of Hubei Province, Wuhan, Hubei, P.R. ChinaWe report a case of prenatal diagnosis of mosaicism for chromosome t (7; 14) with a favorable fetal outcome. Similar chromosomal abnormalities have been observed in patients with hematologic malignancy. Chromosomal microarray analysis (CMA) revealed no genomic imbalance, prenatal ultrasound examination revealed no intrauterine growth restriction (IUGR) or dysmorphisms in this fetus. Therefore, combination of karyotype analysis, CMA, genetic counseling and prenatal ultrasound will prove a more specific risk evaluation for chromosomal translocation and mosaicism.https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.4946karyotype analysiscmachromosome translocationmosaichematologic malignancyprenatal diagnosis |
| spellingShingle | D. Lu D. Cao Q. Zhao X. Chen Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome Clinical and Experimental Obstetrics & Gynecology karyotype analysis cma chromosome translocation mosaic hematologic malignancy prenatal diagnosis |
| title | Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome |
| title_full | Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome |
| title_fullStr | Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome |
| title_full_unstemmed | Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome |
| title_short | Prenatal diagnosis and genetic counseling of mosaicism for chromosome t (7; 14) with a favorable outcome |
| title_sort | prenatal diagnosis and genetic counseling of mosaicism for chromosome t 7 14 with a favorable outcome |
| topic | karyotype analysis cma chromosome translocation mosaic hematologic malignancy prenatal diagnosis |
| url | https://www.imrpress.com/journal/CEOG/47/3/10.31083/j.ceog.2020.03.4946 |
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