Expression and Function of Organic Anion Transporting Polypeptides in the Human Brain: Physiological and Pharmacological Implications

Expression and Function of Organic Anion Transporting Polypeptides in the Human Brain: Physiological and Pharmacological Implications

The central nervous system (CNS) is an important pharmacological target, but it is very effectively protected by the blood–brain barrier (BBB), thereby impairing the efficacy of many potential active compounds as they are unable to cross this barrier. Among others, membranous efflux transporters lik...

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Bibliographic Details
Main Authors: Anima M. Schäfer, Henriette E. Meyer zu Schwabedissen, Markus Grube
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceutics
Subjects:
brain
blood–brain barrier
OATP
expression
neurosteroids
substrates
Online Access:https://www.mdpi.com/1999-4923/13/6/834

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