Critical Neurotransmitters in the Neuroimmune Network
Immune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and transmembrane receptors and ligands, membrane vesicles, junctions, ligand and voltage-gated ion channe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.01869/full |
| _version_ | 1818512045239173120 |
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| author | Thomas Wesley Hodo Thomas Wesley Hodo Thomas Wesley Hodo Maria Teresa Prudente de Aquino Akiko Shimamoto Anil Shanker Anil Shanker Anil Shanker Anil Shanker Anil Shanker |
| author_facet | Thomas Wesley Hodo Thomas Wesley Hodo Thomas Wesley Hodo Maria Teresa Prudente de Aquino Akiko Shimamoto Anil Shanker Anil Shanker Anil Shanker Anil Shanker Anil Shanker |
| author_sort | Thomas Wesley Hodo |
| collection | DOAJ |
| description | Immune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and transmembrane receptors and ligands, membrane vesicles, junctions, ligand and voltage-gated ion channels, and transporters. During a crosstalk between the nervous system and the immune system these modes of cellular communication and the downstream signal transduction events are influenced by neurotransmitters present in the local tissue environments in an autocrine or paracrine fashion. Neurotransmitters thus influence innate and adaptive immune responses. In addition, immune cells send signals to the brain through cytokines, and are present in the brain to influence neural responses. Altered communication between the nervous and immune systems is emerging as a common feature in neurodegenerative and immunopathological diseases. Here, we present the mechanistic frameworks of immunostimulatory and immunosuppressive effects critical neurotransmitters — dopamine (3,4-dihydroxyphenethylamine), serotonin (5-hydroxytryptamine), substance P (trifluoroacetate salt powder), and L-glutamate — exert on lymphocytes and non-lymphoid immune cells. Furthermore, we discuss the possible roles neurotransmitter-driven neuroimmune networks play in the pathogenesis of neurodegenerative disorders, autoimmune diseases, cancer, and outline potential clinical implications of balancing neuroimmune crosstalk by therapeutic modulation. |
| first_indexed | 2024-12-10T23:41:09Z |
| format | Article |
| id | doaj.art-877c682333ab4633967aad55bf9a3146 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T23:41:09Z |
| publishDate | 2020-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-877c682333ab4633967aad55bf9a31462022-12-22T01:29:02ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-08-011110.3389/fimmu.2020.01869523925Critical Neurotransmitters in the Neuroimmune NetworkThomas Wesley Hodo0Thomas Wesley Hodo1Thomas Wesley Hodo2Maria Teresa Prudente de Aquino3Akiko Shimamoto4Anil Shanker5Anil Shanker6Anil Shanker7Anil Shanker8Anil Shanker9Department of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United StatesDepartment of Microbiology and Immunology, Meharry Medical College School of Medicine, Nashville, TN, United StatesSchool of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United StatesDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United StatesDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United StatesDepartment of Biochemistry, Cancer Biology, Neuroscience and Pharmacology, Meharry Medical College School of Medicine, Nashville, TN, United StatesSchool of Graduate Studies and Research, Meharry Medical College, Nashville, TN, United StatesHost-Tumor Interactions Research Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, United StatesVanderbilt Center for Immunobiology, Vanderbilt University Medical Center, Nashville, TN, United StatesVanderbilt Institute for Infection, Immunology and Inflammation, Vanderbilt University Medical Center, Nashville, TN, United StatesImmune cells rely on cell-cell communication to specify and fine-tune their responses. They express an extensive network of cell communication modes, including a vast repertoire of cell surface and transmembrane receptors and ligands, membrane vesicles, junctions, ligand and voltage-gated ion channels, and transporters. During a crosstalk between the nervous system and the immune system these modes of cellular communication and the downstream signal transduction events are influenced by neurotransmitters present in the local tissue environments in an autocrine or paracrine fashion. Neurotransmitters thus influence innate and adaptive immune responses. In addition, immune cells send signals to the brain through cytokines, and are present in the brain to influence neural responses. Altered communication between the nervous and immune systems is emerging as a common feature in neurodegenerative and immunopathological diseases. Here, we present the mechanistic frameworks of immunostimulatory and immunosuppressive effects critical neurotransmitters — dopamine (3,4-dihydroxyphenethylamine), serotonin (5-hydroxytryptamine), substance P (trifluoroacetate salt powder), and L-glutamate — exert on lymphocytes and non-lymphoid immune cells. Furthermore, we discuss the possible roles neurotransmitter-driven neuroimmune networks play in the pathogenesis of neurodegenerative disorders, autoimmune diseases, cancer, and outline potential clinical implications of balancing neuroimmune crosstalk by therapeutic modulation.https://www.frontiersin.org/article/10.3389/fimmu.2020.01869/fullT cell neuroimmunologydopamineglutamateserotoninsubstance Pcancer |
| spellingShingle | Thomas Wesley Hodo Thomas Wesley Hodo Thomas Wesley Hodo Maria Teresa Prudente de Aquino Akiko Shimamoto Anil Shanker Anil Shanker Anil Shanker Anil Shanker Anil Shanker Critical Neurotransmitters in the Neuroimmune Network Frontiers in Immunology T cell neuroimmunology dopamine glutamate serotonin substance P cancer |
| title | Critical Neurotransmitters in the Neuroimmune Network |
| title_full | Critical Neurotransmitters in the Neuroimmune Network |
| title_fullStr | Critical Neurotransmitters in the Neuroimmune Network |
| title_full_unstemmed | Critical Neurotransmitters in the Neuroimmune Network |
| title_short | Critical Neurotransmitters in the Neuroimmune Network |
| title_sort | critical neurotransmitters in the neuroimmune network |
| topic | T cell neuroimmunology dopamine glutamate serotonin substance P cancer |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.01869/full |
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