Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study
Abstract Background The effects of early‐life exposure to house dust mite allergen and endotoxin on the development of asthma are unclear in the literature. We investigated the association of early‐life exposure (0–36 months old) to house dust mite allergen and endotoxin with asthma incidence. Metho...
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| Format: | Article |
| Language: | English |
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Wiley
2021-10-01
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| Series: | Clinical and Translational Allergy |
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| Online Access: | https://doi.org/10.1002/clt2.12071 |
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| author | Hideki Hasunuma Yoshiko Yoda Narumi Tokuda Naoko Taniguchi Yasuhiro Takeshima Masayuki Shima The Japan Environment and Children's Study (JECS) Group |
| author_facet | Hideki Hasunuma Yoshiko Yoda Narumi Tokuda Naoko Taniguchi Yasuhiro Takeshima Masayuki Shima The Japan Environment and Children's Study (JECS) Group |
| author_sort | Hideki Hasunuma |
| collection | DOAJ |
| description | Abstract Background The effects of early‐life exposure to house dust mite allergen and endotoxin on the development of asthma are unclear in the literature. We investigated the association of early‐life exposure (0–36 months old) to house dust mite allergen and endotoxin with asthma incidence. Methods In this novel, large‐scale, nationwide birth cohort study, 5017 participants were randomly selected from those who met the eligibility criteria. House dust was vacuum‐sampled from the children's mattresses within homes and assayed for the presence of dust mite allergen (Der 1) and endotoxin. The participants were classified into four quartiles (Q1–Q4) according to exposure levels. We defined the incidence of asthma and wheezing using questionnaires at 12, 24, and 36 months old. Odds ratios (ORs) of the incidence of asthma and wheezing by age in Der 1 and endotoxin exposure level were estimated using logistic regression. Results The cumulative incidence rates of asthma and wheezing during 0–36 months were 10.4% and 38.1%, respectively. Significant ORs were observed in asthma onset during 12–24 months old, asthma onset during 24–36 months old, and wheezing onset during 0–12 months old in the Q4 Der 1 group. In the Q4 endotoxin group, significant positive associations between endotoxin exposure and asthma (OR 2.00, 95% confidence interval [CI]: 1.03–3.85) and wheezing (OR 1.78, 95% CI: 1.01–3.12) onset during 24–36 months old were found. Conclusions Our results indicated that high levels of early‐life exposure to Der 1 and endotoxin in mattresses may be involved in the development of asthma. |
| first_indexed | 2024-04-11T20:07:15Z |
| format | Article |
| id | doaj.art-877cabae71054433b9a7c074c6bbd2b0 |
| institution | Directory Open Access Journal |
| issn | 2045-7022 |
| language | English |
| last_indexed | 2024-04-11T20:07:15Z |
| publishDate | 2021-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Translational Allergy |
| spelling | doaj.art-877cabae71054433b9a7c074c6bbd2b02022-12-22T04:05:18ZengWileyClinical and Translational Allergy2045-70222021-10-01118n/an/a10.1002/clt2.12071Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's StudyHideki Hasunuma0Yoshiko Yoda1Narumi Tokuda2Naoko Taniguchi3Yasuhiro Takeshima4Masayuki Shima5The Japan Environment and Children's Study (JECS) GroupDepartment of Public Health Hyogo College of Medicine Nishinomiya JapanDepartment of Public Health Hyogo College of Medicine Nishinomiya JapanHyogo Regional Centre for the Japan Environment and Children's Study Nishinomiya JapanHyogo Regional Centre for the Japan Environment and Children's Study Nishinomiya JapanDepartment of Pediatrics Hyogo College of Medicine Nishinomiya JapanDepartment of Public Health Hyogo College of Medicine Nishinomiya JapanAbstract Background The effects of early‐life exposure to house dust mite allergen and endotoxin on the development of asthma are unclear in the literature. We investigated the association of early‐life exposure (0–36 months old) to house dust mite allergen and endotoxin with asthma incidence. Methods In this novel, large‐scale, nationwide birth cohort study, 5017 participants were randomly selected from those who met the eligibility criteria. House dust was vacuum‐sampled from the children's mattresses within homes and assayed for the presence of dust mite allergen (Der 1) and endotoxin. The participants were classified into four quartiles (Q1–Q4) according to exposure levels. We defined the incidence of asthma and wheezing using questionnaires at 12, 24, and 36 months old. Odds ratios (ORs) of the incidence of asthma and wheezing by age in Der 1 and endotoxin exposure level were estimated using logistic regression. Results The cumulative incidence rates of asthma and wheezing during 0–36 months were 10.4% and 38.1%, respectively. Significant ORs were observed in asthma onset during 12–24 months old, asthma onset during 24–36 months old, and wheezing onset during 0–12 months old in the Q4 Der 1 group. In the Q4 endotoxin group, significant positive associations between endotoxin exposure and asthma (OR 2.00, 95% confidence interval [CI]: 1.03–3.85) and wheezing (OR 1.78, 95% CI: 1.01–3.12) onset during 24–36 months old were found. Conclusions Our results indicated that high levels of early‐life exposure to Der 1 and endotoxin in mattresses may be involved in the development of asthma.https://doi.org/10.1002/clt2.12071asthmadust miteearly lifeendotoxinwheeze |
| spellingShingle | Hideki Hasunuma Yoshiko Yoda Narumi Tokuda Naoko Taniguchi Yasuhiro Takeshima Masayuki Shima The Japan Environment and Children's Study (JECS) Group Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study Clinical and Translational Allergy asthma dust mite early life endotoxin wheeze |
| title | Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study |
| title_full | Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study |
| title_fullStr | Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study |
| title_full_unstemmed | Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study |
| title_short | Effects of early‐life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing: The Japan Environment and Children's Study |
| title_sort | effects of early life exposure to dust mite allergen and endotoxin on the development of asthma and wheezing the japan environment and children s study |
| topic | asthma dust mite early life endotoxin wheeze |
| url | https://doi.org/10.1002/clt2.12071 |
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