Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome

Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome

Pseudoexfoliation (PEX) syndrome, a stress-induced fibrotic matrix process, is the most common recognizable cause of open-angle glaucoma worldwide. The recent identification of PEX-associated gene variants uncovered the vitamin A metabolic pathway as a factor influencing the risk of disease. In this...

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Bibliographic Details
Main Authors: Matthias Zenkel, Ursula Hoja, Andreas Gießl, Daniel Berner, Bettina Hohberger, Julia M. Weller, Loretta König, Lisa Hübner, Thomas A. Ostermann, Gabriele C. Gusek-Schneider, Friedrich E. Kruse, Francesca Pasutto, Ursula Schlötzer-Schrehardt
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:International Journal of Molecular Sciences
Subjects:
pseudoexfoliation syndrome
pseudoexfoliation glaucoma
retinol
retinoic acid
extracellular matrix
fibrosis
Online Access:https://www.mdpi.com/1422-0067/23/11/5977

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