Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/β-catenin positive feedback loop

Targeting Trop2 by Bruceine D suppresses breast cancer metastasis by blocking Trop2/β-catenin positive feedback loop

Introduction: Tumor-associated calcium signal transducer 2 (Trop2) has been used as a transport gate for cytotoxic agents into cells in antibody–drug conjugate designs because of its expression in a wide range of solid tumors. However, the specific role of Trop2 itself in breast cancer progression r...

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Bibliographic Details
Main Authors: Wenjuan Tang, Yu Hu, Kaihui Tu, Zhengyan Gong, Man Zhu, Tianfeng Yang, Ammar Sarwar, Bingling Dai, Dongdong Zhang, Yingzhuan Zhan, Yanmin Zhang
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Journal of Advanced Research
Subjects:
Trop2
β-catenin
Breast cancer
Metastasis
Lung colonization
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123223001509

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