Controlled electroactive release from solid-state conductive elastomer electrodes
This work highlights the development of a conductive elastomer (CE) based electrophoretic platform that enables the transfer of charged molecules from a solid-state CE electrode directly to targeted tissues. Using an elastomer-based electrode containing poly (3,4-ethylenedioxythiophene) nanowires, c...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006423003435 |
| _version_ | 1797404584805662720 |
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| author | Christopher A.R. Chapman Shanila Fernandez-Patel Nusrat Jahan Estelle A. Cuttaz Alexey Novikov Josef A. Goding Rylie A. Green |
| author_facet | Christopher A.R. Chapman Shanila Fernandez-Patel Nusrat Jahan Estelle A. Cuttaz Alexey Novikov Josef A. Goding Rylie A. Green |
| author_sort | Christopher A.R. Chapman |
| collection | DOAJ |
| description | This work highlights the development of a conductive elastomer (CE) based electrophoretic platform that enables the transfer of charged molecules from a solid-state CE electrode directly to targeted tissues. Using an elastomer-based electrode containing poly (3,4-ethylenedioxythiophene) nanowires, controlled electrophoretic delivery of methylene blue (MB) and fluorescein (FLSC) was achieved with applied voltage. Electroactive release of positively charged MB and negatively charged FLSC achieved 33.19 ± 6.47 μg release of MB and 22.36 ± 3.05 μg release of FLSC, a 24 and 20-fold increase in comparison to inhibitory voltages over 1 h. Additionally, selective, and sequential release of the two oppositely charged molecules from a single CE device was demonstrated, showing the potential of this device to be used in multi-drug treatments. |
| first_indexed | 2024-03-09T02:57:08Z |
| format | Article |
| id | doaj.art-877ec513699f4c53b6d4a36604ae6aa4 |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-03-09T02:57:08Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-877ec513699f4c53b6d4a36604ae6aa42023-12-05T04:15:41ZengElsevierMaterials Today Bio2590-00642023-12-0123100883Controlled electroactive release from solid-state conductive elastomer electrodesChristopher A.R. Chapman0Shanila Fernandez-Patel1Nusrat Jahan2Estelle A. Cuttaz3Alexey Novikov4Josef A. Goding5Rylie A. Green6School of Engineering and Materials Science, Queen Mary University of London, Mile End, London, E1 4NS, UK; Department of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UKTumour Immunogenomics and Immunosurveillance Laboratory, University College London Cancer Institute, London, UKDepartment of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UKDepartment of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UKDepartment of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UKDepartment of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UKDepartment of Bioengineering, Imperial College London, South Kensington, London, SW7 2AZ, UK; Corresponding authorThis work highlights the development of a conductive elastomer (CE) based electrophoretic platform that enables the transfer of charged molecules from a solid-state CE electrode directly to targeted tissues. Using an elastomer-based electrode containing poly (3,4-ethylenedioxythiophene) nanowires, controlled electrophoretic delivery of methylene blue (MB) and fluorescein (FLSC) was achieved with applied voltage. Electroactive release of positively charged MB and negatively charged FLSC achieved 33.19 ± 6.47 μg release of MB and 22.36 ± 3.05 μg release of FLSC, a 24 and 20-fold increase in comparison to inhibitory voltages over 1 h. Additionally, selective, and sequential release of the two oppositely charged molecules from a single CE device was demonstrated, showing the potential of this device to be used in multi-drug treatments.http://www.sciencedirect.com/science/article/pii/S2590006423003435Electrophoretic releaseConductive elastomerConducting polymerControlled releaseTargeted drug delivery |
| spellingShingle | Christopher A.R. Chapman Shanila Fernandez-Patel Nusrat Jahan Estelle A. Cuttaz Alexey Novikov Josef A. Goding Rylie A. Green Controlled electroactive release from solid-state conductive elastomer electrodes Materials Today Bio Electrophoretic release Conductive elastomer Conducting polymer Controlled release Targeted drug delivery |
| title | Controlled electroactive release from solid-state conductive elastomer electrodes |
| title_full | Controlled electroactive release from solid-state conductive elastomer electrodes |
| title_fullStr | Controlled electroactive release from solid-state conductive elastomer electrodes |
| title_full_unstemmed | Controlled electroactive release from solid-state conductive elastomer electrodes |
| title_short | Controlled electroactive release from solid-state conductive elastomer electrodes |
| title_sort | controlled electroactive release from solid state conductive elastomer electrodes |
| topic | Electrophoretic release Conductive elastomer Conducting polymer Controlled release Targeted drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2590006423003435 |
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