Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children
<b>Objectives</b>: To analyze the impact of polycyclic aromatic hydrocarbons (PAHs) in ambient air at the time of delivery and five years of age on cognitive development in five year old children. <b>Materials and Methods</b>: Two cohorts of children born in the years 2013 an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/9/619 |
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| author | Barbora Blazkova Anna Pastorkova Ivo Solansky Milos Veleminsky Milos Veleminsky Katerina Urbancova Veronika Vondraskova Jana Hajslova Jana Pulkrabova Radim J. Sram |
| author_facet | Barbora Blazkova Anna Pastorkova Ivo Solansky Milos Veleminsky Milos Veleminsky Katerina Urbancova Veronika Vondraskova Jana Hajslova Jana Pulkrabova Radim J. Sram |
| author_sort | Barbora Blazkova |
| collection | DOAJ |
| description | <b>Objectives</b>: To analyze the impact of polycyclic aromatic hydrocarbons (PAHs) in ambient air at the time of delivery and five years of age on cognitive development in five year old children. <b>Materials and Methods</b>: Two cohorts of children born in the years 2013 and 2014 from Karvina (Northern Moravia, <i>n</i> = 70) and Ceske Budejovice (Southern Bohemia, <i>n</i> = 99) were studied at the age of five years for their cognitive development related to the exposure to PAHs, determined in the ambient air as the concentration of benzo[a]pyrene (B[a]P) and OH–PAH (hydroxy-PAH) metabolites in urine of the newborns at the time of delivery. As psychological tests, the Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used. <b>Results</b>: Concentrations of B[a]P in the third trimester of mother’s pregnancies were 6.1 ± 4.53 ng/m<sup>3</sup> in Karvina, and 1.19 ± 1.28 ng/m<sup>3</sup> (<i>p</i> < 0.001) in Ceske Budejovice. Neither the outcome of the RCPM test nor the BG test differed between children in Karvina vs. Ceske Budejovice, or boys vs. girls. Cognitive development in five year old children was affected by the higher exposure to PM2.5 during the third trimester in girls in Karvina. <b>Conclusions</b>: We did not observe any significant effect of prenatal PAH exposure on psychological cognitive tests in five year old children. |
| first_indexed | 2024-03-10T16:30:48Z |
| format | Article |
| id | doaj.art-877f4f09ec094625a4633fba90772298 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T16:30:48Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-877f4f09ec094625a4633fba907722982023-11-20T12:52:44ZengMDPI AGBrain Sciences2076-34252020-09-0110961910.3390/brainsci10090619Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old ChildrenBarbora Blazkova0Anna Pastorkova1Ivo Solansky2Milos Veleminsky3Milos Veleminsky4Katerina Urbancova5Veronika Vondraskova6Jana Hajslova7Jana Pulkrabova8Radim J. Sram9Faculty of Health and Social Sciences, University of South Bohemia, 370 05 Ceske Budejovice, Czech RepublicFaculty of Health and Social Sciences, University of South Bohemia, 370 05 Ceske Budejovice, Czech RepublicFaculty of Health and Social Sciences, University of South Bohemia, 370 05 Ceske Budejovice, Czech RepublicFaculty of Health and Social Sciences, University of South Bohemia, 370 05 Ceske Budejovice, Czech RepublicFaculty of Health and Social Sciences, University of South Bohemia, 370 05 Ceske Budejovice, Czech RepublicFaculty of Food and Biochemical Technology, University of Chemistry and Technology, 166 28 Prague, Czech RepublicFaculty of Food and Biochemical Technology, University of Chemistry and Technology, 166 28 Prague, Czech RepublicFaculty of Food and Biochemical Technology, University of Chemistry and Technology, 166 28 Prague, Czech RepublicFaculty of Food and Biochemical Technology, University of Chemistry and Technology, 166 28 Prague, Czech RepublicFaculty of Health and Social Sciences, University of South Bohemia, 370 05 Ceske Budejovice, Czech Republic<b>Objectives</b>: To analyze the impact of polycyclic aromatic hydrocarbons (PAHs) in ambient air at the time of delivery and five years of age on cognitive development in five year old children. <b>Materials and Methods</b>: Two cohorts of children born in the years 2013 and 2014 from Karvina (Northern Moravia, <i>n</i> = 70) and Ceske Budejovice (Southern Bohemia, <i>n</i> = 99) were studied at the age of five years for their cognitive development related to the exposure to PAHs, determined in the ambient air as the concentration of benzo[a]pyrene (B[a]P) and OH–PAH (hydroxy-PAH) metabolites in urine of the newborns at the time of delivery. As psychological tests, the Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used. <b>Results</b>: Concentrations of B[a]P in the third trimester of mother’s pregnancies were 6.1 ± 4.53 ng/m<sup>3</sup> in Karvina, and 1.19 ± 1.28 ng/m<sup>3</sup> (<i>p</i> < 0.001) in Ceske Budejovice. Neither the outcome of the RCPM test nor the BG test differed between children in Karvina vs. Ceske Budejovice, or boys vs. girls. Cognitive development in five year old children was affected by the higher exposure to PM2.5 during the third trimester in girls in Karvina. <b>Conclusions</b>: We did not observe any significant effect of prenatal PAH exposure on psychological cognitive tests in five year old children.https://www.mdpi.com/2076-3425/10/9/619polycyclic aromatic hydrocarbonsOH–PAH metabolites in urinepsychological testscognitive developmentBender Visual Motor Gestalt TestRaven Colored Progressive Matrices |
| spellingShingle | Barbora Blazkova Anna Pastorkova Ivo Solansky Milos Veleminsky Milos Veleminsky Katerina Urbancova Veronika Vondraskova Jana Hajslova Jana Pulkrabova Radim J. Sram Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children Brain Sciences polycyclic aromatic hydrocarbons OH–PAH metabolites in urine psychological tests cognitive development Bender Visual Motor Gestalt Test Raven Colored Progressive Matrices |
| title | Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children |
| title_full | Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children |
| title_fullStr | Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children |
| title_full_unstemmed | Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children |
| title_short | Effect of Polycyclic Aromatic Hydrocarbons Exposure on Cognitive Development in 5 Years Old Children |
| title_sort | effect of polycyclic aromatic hydrocarbons exposure on cognitive development in 5 years old children |
| topic | polycyclic aromatic hydrocarbons OH–PAH metabolites in urine psychological tests cognitive development Bender Visual Motor Gestalt Test Raven Colored Progressive Matrices |
| url | https://www.mdpi.com/2076-3425/10/9/619 |
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