Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts

Blood vessels are crucial in the human body, providing essential nutrients to all tissues while facilitating waste removal. As the incidence of cardiovascular disease rises, the demand for efficient treatments increases concurrently. Currently, the predominant interventions for cardiovascular diseas...

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Main Authors: Daichen Liu, Qingshan Meng, Jinguang Hu
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Polymers
Subjects:
Online Access:https://www.mdpi.com/2073-4360/15/18/3812
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author Daichen Liu
Qingshan Meng
Jinguang Hu
author_facet Daichen Liu
Qingshan Meng
Jinguang Hu
author_sort Daichen Liu
collection DOAJ
description Blood vessels are crucial in the human body, providing essential nutrients to all tissues while facilitating waste removal. As the incidence of cardiovascular disease rises, the demand for efficient treatments increases concurrently. Currently, the predominant interventions for cardiovascular disease are autografts and allografts. Although effective, they present limitations including high costs and inconsistent success rates. Recently, synthetic vascular grafts, made from artificial materials, have emerged as promising alternatives to traditional methods. Among these materials, bacterial cellulose hydrogel exhibits significant potential for tissue engineering applications, particularly in developing nanoscale platforms that regulate cell behavior and promote tissue regeneration, attributed to its notable physicochemical and biocompatible properties. This study reviews recent progress in fabricating engineered vascular grafts using bacterial nanocellulose, demonstrating the efficacy of bacterial cellulose hydrogel as a biomaterial for synthetic vascular grafts, specifically for stimulating angiogenesis and neovascularization.
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spelling doaj.art-87801160fbd04bfbbbdab4c35ebfc0052023-11-19T12:36:10ZengMDPI AGPolymers2073-43602023-09-011518381210.3390/polym15183812Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular GraftsDaichen Liu0Qingshan Meng1Jinguang Hu2Department of Chemical and Petroleum Engineering, University of Calgary, 2500 University Drive, Calgary, AB T2N 1N4, CanadaDepartment of Chemical and Petroleum Engineering, University of Calgary, 2500 University Drive, Calgary, AB T2N 1N4, CanadaDepartment of Chemical and Petroleum Engineering, University of Calgary, 2500 University Drive, Calgary, AB T2N 1N4, CanadaBlood vessels are crucial in the human body, providing essential nutrients to all tissues while facilitating waste removal. As the incidence of cardiovascular disease rises, the demand for efficient treatments increases concurrently. Currently, the predominant interventions for cardiovascular disease are autografts and allografts. Although effective, they present limitations including high costs and inconsistent success rates. Recently, synthetic vascular grafts, made from artificial materials, have emerged as promising alternatives to traditional methods. Among these materials, bacterial cellulose hydrogel exhibits significant potential for tissue engineering applications, particularly in developing nanoscale platforms that regulate cell behavior and promote tissue regeneration, attributed to its notable physicochemical and biocompatible properties. This study reviews recent progress in fabricating engineered vascular grafts using bacterial nanocellulose, demonstrating the efficacy of bacterial cellulose hydrogel as a biomaterial for synthetic vascular grafts, specifically for stimulating angiogenesis and neovascularization.https://www.mdpi.com/2073-4360/15/18/3812bacterial nanocellulosevascular graftsnatural hydrogel
spellingShingle Daichen Liu
Qingshan Meng
Jinguang Hu
Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts
Polymers
bacterial nanocellulose
vascular grafts
natural hydrogel
title Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts
title_full Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts
title_fullStr Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts
title_full_unstemmed Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts
title_short Bacterial Nanocellulose Hydrogel: A Promising Alternative Material for the Fabrication of Engineered Vascular Grafts
title_sort bacterial nanocellulose hydrogel a promising alternative material for the fabrication of engineered vascular grafts
topic bacterial nanocellulose
vascular grafts
natural hydrogel
url https://www.mdpi.com/2073-4360/15/18/3812
work_keys_str_mv AT daichenliu bacterialnanocellulosehydrogelapromisingalternativematerialforthefabricationofengineeredvasculargrafts
AT qingshanmeng bacterialnanocellulosehydrogelapromisingalternativematerialforthefabricationofengineeredvasculargrafts
AT jinguanghu bacterialnanocellulosehydrogelapromisingalternativematerialforthefabricationofengineeredvasculargrafts