Engineering <it>Escherichia coli</it> to increase plasmid DNA production in high cell-density cultivations in batch mode

Engineering <it>Escherichia coli</it> to increase plasmid DNA production in high cell-density cultivations in batch mode

<p>Abstract</p> <p>Background</p> <p>Plasmid DNA (pDNA) is a promising molecule for therapeutic applications. pDNA is produced by <it>Escherichia coli</it> in high cell-density cultivations (HCDC) using fed-batch mode. The typical limitations of such cultiva...

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Bibliographic Details
Main Authors: Borja Gheorghe M, Meza Mora Eugenio, Barrón Blanca, Gosset Guillermo, Ramírez Octavio T, Lara Alvaro R
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Microbial Cell Factories
Subjects:
Plasmid DNA
DNA vaccines
Overflow metabolism
<it>E. coli</it>
Batch cultivation
Acetate
Online Access:http://www.microbialcellfactories.com/content/11/1/132

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