Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys

Mesenchymal-derived extracellular vesicles enhance microglia-mediated synapse remodeling after cortical injury in aging Rhesus monkeys

Abstract Understanding the microglial neuro-immune interactions in the primate brain is vital to developing therapeutics for cortical injury, such as stroke or traumatic brain injury. Our previous work showed that mesenchymal-derived extracellular vesicles (MSC-EVs) enhanced motor recovery in aged r...

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Bibliographic Details
Main Authors: Yuxin Zhou, Hrishti Bhatt, Chromewell A. Mojica, Hongqi Xin, Monica A. Pessina, Douglas L. Rosene, Tara L. Moore, Maria Medalla
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Neuroinflammation
Subjects:
Cortical injury
Synaptic plasticity
Neuroinflammation
Extracellular vesicles
Microglia
C1q
Online Access:https://doi.org/10.1186/s12974-023-02880-0

Internet

https://doi.org/10.1186/s12974-023-02880-0

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