Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization

Structure–Activity Relationship Studies of Chalcones and Diarylpentanoids with Antitumor Activity: Potency and Selectivity Optimization

We previously reported that chalcone <b>CM-M345</b> (<b>1</b>) and diarylpentanoid <b>BP-C4</b> (<b>2</b>) induced p53-dependent growth inhibitory activity in human cancer cells. Herein, <b>CM-M345</b> (<b>1</b>) and <b>BP...

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Bibliographic Details
Main Authors: Joana Moreira, Joana B. Loureiro, Danilo Correia, Andreia Palmeira, Madalena M. Pinto, Lucília Saraiva, Honorina Cidade
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Pharmaceuticals
Subjects:
chalcones
diarylpentanoids
antitumor activity
p53-MDM2
in silico studies
Online Access:https://www.mdpi.com/1424-8247/16/10/1354

Internet

https://www.mdpi.com/1424-8247/16/10/1354

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