The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research
Because of the problem to evaluate biological activity in water-soluble substances in all phases of preclinical and clinical studies, the research work enabled to develop the original solvent for poorly soluble compounds based on substances for parenteral nutrition. The main aim is to examine the im...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | Journal of Advanced Pharmaceutical Technology & Research |
| Subjects: | |
| Online Access: | http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=1;spage=9;epage=14;aulast=Urakov |
| _version_ | 1818049936863789056 |
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| author | Aleksandr L Urakov Ilshat G Mustafin Aleksandr V Samorodov Felix Kh Kamilov Ferkat A Khaliullin |
| author_facet | Aleksandr L Urakov Ilshat G Mustafin Aleksandr V Samorodov Felix Kh Kamilov Ferkat A Khaliullin |
| author_sort | Aleksandr L Urakov |
| collection | DOAJ |
| description | Because of the problem to evaluate biological activity in water-soluble substances in all phases of preclinical and clinical studies, the research work enabled to develop the original solvent for poorly soluble compounds based on substances for parenteral nutrition. The main aim is to examine the impact of the original solvent based on substances for parenteral nutrition on biological systems exemplified by the hemostatic system, characterized by sensitivity and variability of the effects in response to any impact, and its comparison with the solvents that are conventional in pharmacological research. Experimental work is performed according to the “guidance on preclinical research of new pharmacological substances” in vitro. The findings show that traditional solvents at low dosages affect all the researched indicators of the hemostasis system. The smallest effect in respect of the hemostatic system was characterized by ethanol, and the most apparent antiaggregational effect was registered with dioxane. 10% concentration of original blend of lipids made no effect on hemostasis system. Thus, according to their own findings and experience in application of lipid emulsions as substances of parenteral nutrition, they can be considered to be an adequate solvent in all phases of preclinical and clinical studies of new drugs. |
| first_indexed | 2024-12-10T10:45:30Z |
| format | Article |
| id | doaj.art-8787348a318d495b9f9806a1f57b3934 |
| institution | Directory Open Access Journal |
| issn | 2231-4040 0976-2094 |
| language | English |
| last_indexed | 2024-12-10T10:45:30Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Advanced Pharmaceutical Technology & Research |
| spelling | doaj.art-8787348a318d495b9f9806a1f57b39342022-12-22T01:52:10ZengWolters Kluwer Medknow PublicationsJournal of Advanced Pharmaceutical Technology & Research2231-40400976-20942018-01-019191410.4103/japtr.JAPTR_280_17The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological researchAleksandr L UrakovIlshat G MustafinAleksandr V SamorodovFelix Kh KamilovFerkat A KhaliullinBecause of the problem to evaluate biological activity in water-soluble substances in all phases of preclinical and clinical studies, the research work enabled to develop the original solvent for poorly soluble compounds based on substances for parenteral nutrition. The main aim is to examine the impact of the original solvent based on substances for parenteral nutrition on biological systems exemplified by the hemostatic system, characterized by sensitivity and variability of the effects in response to any impact, and its comparison with the solvents that are conventional in pharmacological research. Experimental work is performed according to the “guidance on preclinical research of new pharmacological substances” in vitro. The findings show that traditional solvents at low dosages affect all the researched indicators of the hemostasis system. The smallest effect in respect of the hemostatic system was characterized by ethanol, and the most apparent antiaggregational effect was registered with dioxane. 10% concentration of original blend of lipids made no effect on hemostasis system. Thus, according to their own findings and experience in application of lipid emulsions as substances of parenteral nutrition, they can be considered to be an adequate solvent in all phases of preclinical and clinical studies of new drugs.http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=1;spage=9;epage=14;aulast=UrakovHemostasis systemlipid emulsionnonclinical and clinical studiesoff-label use |
| spellingShingle | Aleksandr L Urakov Ilshat G Mustafin Aleksandr V Samorodov Felix Kh Kamilov Ferkat A Khaliullin The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research Journal of Advanced Pharmaceutical Technology & Research Hemostasis system lipid emulsion nonclinical and clinical studies off-label use |
| title | The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research |
| title_full | The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research |
| title_fullStr | The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research |
| title_full_unstemmed | The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research |
| title_short | The off-label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research |
| title_sort | off label use of drugs for parenteral nutrition as a solvent of substances slightly soluble in water in pharmacological research |
| topic | Hemostasis system lipid emulsion nonclinical and clinical studies off-label use |
| url | http://www.japtr.org/article.asp?issn=2231-4040;year=2018;volume=9;issue=1;spage=9;epage=14;aulast=Urakov |
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