An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial Tree
Determining the impact of inter-subject variability on airflow pattern and nanoparticle deposition in the human respiratory system is necessary to generate population-representative models, useful for several biomedical engineering applications. Thus, the overall research objective is to quantitativ...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/4/4/90 |
| _version_ | 1827841523477118976 |
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| author | Yu Feng Jianan Zhao Xiaole Chen Jiang Lin |
| author_facet | Yu Feng Jianan Zhao Xiaole Chen Jiang Lin |
| author_sort | Yu Feng |
| collection | DOAJ |
| description | Determining the impact of inter-subject variability on airflow pattern and nanoparticle deposition in the human respiratory system is necessary to generate population-representative models, useful for several biomedical engineering applications. Thus, the overall research objective is to quantitatively correlate geometric parameters and coupled transport characteristics of air, vapor, and nanoparticles. Focusing on identifying morphological parameters that significantly influence airflow field and nanoparticle transport, an experimentally validated computational fluid-particle dynamics (CFPD) model was employed to simulate airflow pattern in three human lung-airway configurations. The numerical results will be used to generate guidelines to construct a representative geometry of the human respiratory system. |
| first_indexed | 2024-03-12T07:52:56Z |
| format | Article |
| id | doaj.art-878839fb2693413794f3edd71aa91e7a |
| institution | Directory Open Access Journal |
| issn | 2306-5354 |
| language | English |
| last_indexed | 2024-03-12T07:52:56Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Bioengineering |
| spelling | doaj.art-878839fb2693413794f3edd71aa91e7a2023-09-02T20:26:53ZengMDPI AGBioengineering2306-53542017-11-01449010.3390/bioengineering4040090bioengineering4040090An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial TreeYu Feng0Jianan Zhao1Xiaole Chen2Jiang Lin3School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USASchool of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USASchool of Energy and Environment, Southeast University, Nanjing 210018, ChinaZhejiang University of Science and Technology, Hangzhou 310023, ChinaDetermining the impact of inter-subject variability on airflow pattern and nanoparticle deposition in the human respiratory system is necessary to generate population-representative models, useful for several biomedical engineering applications. Thus, the overall research objective is to quantitatively correlate geometric parameters and coupled transport characteristics of air, vapor, and nanoparticles. Focusing on identifying morphological parameters that significantly influence airflow field and nanoparticle transport, an experimentally validated computational fluid-particle dynamics (CFPD) model was employed to simulate airflow pattern in three human lung-airway configurations. The numerical results will be used to generate guidelines to construct a representative geometry of the human respiratory system.https://www.mdpi.com/2306-5354/4/4/90inter-subject variabilitycomputational fluid-particle dynamics (CFPD)lung airflow regime |
| spellingShingle | Yu Feng Jianan Zhao Xiaole Chen Jiang Lin An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial Tree Bioengineering inter-subject variability computational fluid-particle dynamics (CFPD) lung airflow regime |
| title | An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial Tree |
| title_full | An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial Tree |
| title_fullStr | An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial Tree |
| title_full_unstemmed | An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial Tree |
| title_short | An In Silico Subject-Variability Study of Upper Airway Morphological Influence on the Airflow Regime in a Tracheobronchial Tree |
| title_sort | in silico subject variability study of upper airway morphological influence on the airflow regime in a tracheobronchial tree |
| topic | inter-subject variability computational fluid-particle dynamics (CFPD) lung airflow regime |
| url | https://www.mdpi.com/2306-5354/4/4/90 |
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