The role of EBV-encoded miRNA in EBV-associated gastric cancer
Epstein-Barr virus (human herpesvirus 4, EBV) is a linear double-stranded DNA virus that infects over 90% of the population worldwide. However, our understanding of EBV’s contribution to tumorigenesis of EBV-associated GC (EBVaGC) remains incomplete. Recent advancements in EBVaGC research have highl...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1204030/full |
| _version_ | 1827926330819215360 |
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| author | Ting Liu Xiaoying Zhou Zhe Zhang Zhe Zhang Yutao Qin Rensheng Wang Rensheng Wang Yanning Qin Yuqi Huang Yingxi Mo Tingting Huang Tingting Huang |
| author_facet | Ting Liu Xiaoying Zhou Zhe Zhang Zhe Zhang Yutao Qin Rensheng Wang Rensheng Wang Yanning Qin Yuqi Huang Yingxi Mo Tingting Huang Tingting Huang |
| author_sort | Ting Liu |
| collection | DOAJ |
| description | Epstein-Barr virus (human herpesvirus 4, EBV) is a linear double-stranded DNA virus that infects over 90% of the population worldwide. However, our understanding of EBV’s contribution to tumorigenesis of EBV-associated GC (EBVaGC) remains incomplete. Recent advancements in EBVaGC research have highlighted that EBV-encoded microRNAs (miRNAs) play prominent roles in critical cellular processes such as migration, cell cycle, apoptosis, cell proliferation, immune response, and autophagy. Notably, the largest group of EBV-encoded miRNAs, known as BamHI-A rightward transcripts (BARTs), exhibit bidirectional effects in EBVaGC. For instance, they present both anti-apoptotic and pro-apoptotic functions and enhance chemosensitivity while also conferring resistance to 5-fluorouracil. Despite these findings, the comprehensive mechanisms through which miRNAs contribute to EBVaGC are yet to be fully elucidated. In this work, we summarize the current evidence of the roles of miRNA in EBVaGC, particularly with the application of multi-omic techniques. Additionally, we discuss the application of miRNA in EBVaGC in retrospective analyses and provide novel perspectives on the use of miRNA in EBVaGC in translational medicine. |
| first_indexed | 2024-03-13T05:37:37Z |
| format | Article |
| id | doaj.art-8788a8f30aba4eb28a1e4ae20ca32bca |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-13T05:37:37Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8788a8f30aba4eb28a1e4ae20ca32bca2023-06-14T05:23:38ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-06-011310.3389/fonc.2023.12040301204030The role of EBV-encoded miRNA in EBV-associated gastric cancerTing Liu0Xiaoying Zhou1Zhe Zhang2Zhe Zhang3Yutao Qin4Rensheng Wang5Rensheng Wang6Yanning Qin7Yuqi Huang8Yingxi Mo9Tingting Huang10Tingting Huang11Department of Radiotherapy, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of High-Incidence-Tumor Prevention and Treatment, Ministry of Education, Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of High-Incidence-Tumor Prevention and Treatment, Ministry of Education, Guangxi Medical University, Nanning, ChinaDepartment of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiotherapy, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiotherapy, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of High-Incidence-Tumor Prevention and Treatment, Ministry of Education, Guangxi Medical University, Nanning, ChinaSchool of Basic Medical Sciences, Guangxi Medical University, Nanning, ChinaSchool of Basic Medical Sciences, Guangxi Medical University, Nanning, ChinaDepartment of Research, Guangxi Medical University Cancer Hospital, Nanning, ChinaDepartment of Radiotherapy, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaGuangxi Key Laboratory of High-Incidence-Tumor Prevention and Treatment, Ministry of Education, Guangxi Medical University, Nanning, ChinaEpstein-Barr virus (human herpesvirus 4, EBV) is a linear double-stranded DNA virus that infects over 90% of the population worldwide. However, our understanding of EBV’s contribution to tumorigenesis of EBV-associated GC (EBVaGC) remains incomplete. Recent advancements in EBVaGC research have highlighted that EBV-encoded microRNAs (miRNAs) play prominent roles in critical cellular processes such as migration, cell cycle, apoptosis, cell proliferation, immune response, and autophagy. Notably, the largest group of EBV-encoded miRNAs, known as BamHI-A rightward transcripts (BARTs), exhibit bidirectional effects in EBVaGC. For instance, they present both anti-apoptotic and pro-apoptotic functions and enhance chemosensitivity while also conferring resistance to 5-fluorouracil. Despite these findings, the comprehensive mechanisms through which miRNAs contribute to EBVaGC are yet to be fully elucidated. In this work, we summarize the current evidence of the roles of miRNA in EBVaGC, particularly with the application of multi-omic techniques. Additionally, we discuss the application of miRNA in EBVaGC in retrospective analyses and provide novel perspectives on the use of miRNA in EBVaGC in translational medicine.https://www.frontiersin.org/articles/10.3389/fonc.2023.1204030/fullEpstein-Barr virusgastric cancerMicroRNAscarcinogenesisclinical application |
| spellingShingle | Ting Liu Xiaoying Zhou Zhe Zhang Zhe Zhang Yutao Qin Rensheng Wang Rensheng Wang Yanning Qin Yuqi Huang Yingxi Mo Tingting Huang Tingting Huang The role of EBV-encoded miRNA in EBV-associated gastric cancer Frontiers in Oncology Epstein-Barr virus gastric cancer MicroRNAs carcinogenesis clinical application |
| title | The role of EBV-encoded miRNA in EBV-associated gastric cancer |
| title_full | The role of EBV-encoded miRNA in EBV-associated gastric cancer |
| title_fullStr | The role of EBV-encoded miRNA in EBV-associated gastric cancer |
| title_full_unstemmed | The role of EBV-encoded miRNA in EBV-associated gastric cancer |
| title_short | The role of EBV-encoded miRNA in EBV-associated gastric cancer |
| title_sort | role of ebv encoded mirna in ebv associated gastric cancer |
| topic | Epstein-Barr virus gastric cancer MicroRNAs carcinogenesis clinical application |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1204030/full |
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