Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development
Taurine (2-aminoethanesulfonic acid) plays an important role in various physiological functions and is abundant in the brain and skeletal muscle. Extracellular taurine is an endogenous agonist of gamma-aminobutyric acid type A and glycine receptors. Taurine actively accumulates in cells via the taur...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/7/631 |
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| author | Miho Watanabe Takashi Ito Atsuo Fukuda |
| author_facet | Miho Watanabe Takashi Ito Atsuo Fukuda |
| author_sort | Miho Watanabe |
| collection | DOAJ |
| description | Taurine (2-aminoethanesulfonic acid) plays an important role in various physiological functions and is abundant in the brain and skeletal muscle. Extracellular taurine is an endogenous agonist of gamma-aminobutyric acid type A and glycine receptors. Taurine actively accumulates in cells via the taurine transporter (TauT). Adult taurine-knockout (<i>TauT</i><sup>−/−</sup>) mice exhibit lower body weights and exercise intolerance. To further examine the physiological role of taurine, we examined the effect of its depletion on mouse behavior, startle responses, muscular endurance, and body weight during development from postnatal day 0 (P0) until P60. In the elevated plus maze test, <i>TauT</i><sup>−/−</sup> mice showed decreased anxiety-like behavior. In addition, <i>TauT</i><sup>−/−</sup> mice did not show a startle response to startle stimuli, suggesting they have difficulty hearing. Wire-hang test revealed that muscular endurance was reduced in <i>TauT</i><sup>−/−</sup> mice. Although a reduction of body weight was observed in <i>TauT</i><sup>−/−</sup> mice during the developmental period, changes in body weight during 60% food restriction were similar to wild-type mice. Collectively, these results suggest that taurine has important roles in anxiety-like behavior, hearing, muscular endurance, and maintenance of body weight. |
| first_indexed | 2024-03-09T13:23:28Z |
| format | Article |
| id | doaj.art-878a02ad5f17478a8db4f68f732eae68 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T13:23:28Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-878a02ad5f17478a8db4f68f732eae682023-11-30T21:27:16ZengMDPI AGMetabolites2218-19892022-07-0112763110.3390/metabo12070631Effects of Taurine Depletion on Body Weight and Mouse Behavior during DevelopmentMiho Watanabe0Takashi Ito1Atsuo Fukuda2Department of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, JapanDepartment of Bioscience and Technology, Graduate School of Bioscience and Technology, Fukui Prefectural University, Fukui 910-1195, JapanDepartment of Neurophysiology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, JapanTaurine (2-aminoethanesulfonic acid) plays an important role in various physiological functions and is abundant in the brain and skeletal muscle. Extracellular taurine is an endogenous agonist of gamma-aminobutyric acid type A and glycine receptors. Taurine actively accumulates in cells via the taurine transporter (TauT). Adult taurine-knockout (<i>TauT</i><sup>−/−</sup>) mice exhibit lower body weights and exercise intolerance. To further examine the physiological role of taurine, we examined the effect of its depletion on mouse behavior, startle responses, muscular endurance, and body weight during development from postnatal day 0 (P0) until P60. In the elevated plus maze test, <i>TauT</i><sup>−/−</sup> mice showed decreased anxiety-like behavior. In addition, <i>TauT</i><sup>−/−</sup> mice did not show a startle response to startle stimuli, suggesting they have difficulty hearing. Wire-hang test revealed that muscular endurance was reduced in <i>TauT</i><sup>−/−</sup> mice. Although a reduction of body weight was observed in <i>TauT</i><sup>−/−</sup> mice during the developmental period, changes in body weight during 60% food restriction were similar to wild-type mice. Collectively, these results suggest that taurine has important roles in anxiety-like behavior, hearing, muscular endurance, and maintenance of body weight.https://www.mdpi.com/2218-1989/12/7/631taurinetaurine transporterknockout micebrainskeletal musclebody weight |
| spellingShingle | Miho Watanabe Takashi Ito Atsuo Fukuda Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development Metabolites taurine taurine transporter knockout mice brain skeletal muscle body weight |
| title | Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development |
| title_full | Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development |
| title_fullStr | Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development |
| title_full_unstemmed | Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development |
| title_short | Effects of Taurine Depletion on Body Weight and Mouse Behavior during Development |
| title_sort | effects of taurine depletion on body weight and mouse behavior during development |
| topic | taurine taurine transporter knockout mice brain skeletal muscle body weight |
| url | https://www.mdpi.com/2218-1989/12/7/631 |
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