Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers
<i>Bacillus thuringiensis</i> (Bt) is a gram negative soil bacterium. This bacterium secretes various proteins during different growth phases with an insecticidal potential against many economically important crop pests. One of the important families of Bt proteins is vegetative insectic...
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MDPI AG
2020-08-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/12/8/522 |
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| author | Tahira Syed Muhammad Askari Zhigang Meng Yanyan Li Muhammad Ali Abid Yunxiao Wei Sandui Guo Chengzhen Liang Rui Zhang |
| author_facet | Tahira Syed Muhammad Askari Zhigang Meng Yanyan Li Muhammad Ali Abid Yunxiao Wei Sandui Guo Chengzhen Liang Rui Zhang |
| author_sort | Tahira Syed |
| collection | DOAJ |
| description | <i>Bacillus thuringiensis</i> (Bt) is a gram negative soil bacterium. This bacterium secretes various proteins during different growth phases with an insecticidal potential against many economically important crop pests. One of the important families of Bt proteins is vegetative insecticidal proteins (Vip), which are secreted into the growth medium during vegetative growth. There are three subfamilies of Vip proteins. Vip1 and Vip2 heterodimer toxins have an insecticidal activity against many Coleopteran and Hemipteran pests. Vip3, the most extensively studied family of Vip toxins, is effective against Lepidopteron. Vip proteins do not share homology in sequence and binding sites with Cry proteins, but share similarities at some points in their mechanism of action. Vip3 proteins are expressed as pyramids alongside Cry proteins in crops like maize and cotton, so as to control resistant pests and delay the evolution of resistance. Biotechnological- and in silico-based analyses are promising for the generation of mutant Vip proteins with an enhanced insecticidal activity and broader spectrum of target insects. |
| first_indexed | 2024-03-10T17:27:32Z |
| format | Article |
| id | doaj.art-878adf8140d24f20a7193b7aa581dc42 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-10T17:27:32Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-878adf8140d24f20a7193b7aa581dc422023-11-20T10:08:33ZengMDPI AGToxins2072-66512020-08-0112852210.3390/toxins12080522Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest KillersTahira Syed0Muhammad Askari1Zhigang Meng2Yanyan Li3Muhammad Ali Abid4Yunxiao Wei5Sandui Guo6Chengzhen Liang7Rui Zhang8Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, ChinaBiotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China<i>Bacillus thuringiensis</i> (Bt) is a gram negative soil bacterium. This bacterium secretes various proteins during different growth phases with an insecticidal potential against many economically important crop pests. One of the important families of Bt proteins is vegetative insecticidal proteins (Vip), which are secreted into the growth medium during vegetative growth. There are three subfamilies of Vip proteins. Vip1 and Vip2 heterodimer toxins have an insecticidal activity against many Coleopteran and Hemipteran pests. Vip3, the most extensively studied family of Vip toxins, is effective against Lepidopteron. Vip proteins do not share homology in sequence and binding sites with Cry proteins, but share similarities at some points in their mechanism of action. Vip3 proteins are expressed as pyramids alongside Cry proteins in crops like maize and cotton, so as to control resistant pests and delay the evolution of resistance. Biotechnological- and in silico-based analyses are promising for the generation of mutant Vip proteins with an enhanced insecticidal activity and broader spectrum of target insects.https://www.mdpi.com/2072-6651/12/8/522<i>Bacillus thuringiensis</i>vegetative insecticidal proteinsinsecticidal activityresistancepyramids |
| spellingShingle | Tahira Syed Muhammad Askari Zhigang Meng Yanyan Li Muhammad Ali Abid Yunxiao Wei Sandui Guo Chengzhen Liang Rui Zhang Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers Toxins <i>Bacillus thuringiensis</i> vegetative insecticidal proteins insecticidal activity resistance pyramids |
| title | Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers |
| title_full | Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers |
| title_fullStr | Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers |
| title_full_unstemmed | Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers |
| title_short | Current Insights on Vegetative Insecticidal Proteins (Vip) as Next Generation Pest Killers |
| title_sort | current insights on vegetative insecticidal proteins vip as next generation pest killers |
| topic | <i>Bacillus thuringiensis</i> vegetative insecticidal proteins insecticidal activity resistance pyramids |
| url | https://www.mdpi.com/2072-6651/12/8/522 |
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