Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy
Abstract Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specia...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12951-020-00649-8 |
| _version_ | 1828350792859385856 |
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| author | Chunai Gong Xiaoyan Yu Benming You Yan Wu Rong Wang Lu Han Yujie Wang Shen Gao Yongfang Yuan |
| author_facet | Chunai Gong Xiaoyan Yu Benming You Yan Wu Rong Wang Lu Han Yujie Wang Shen Gao Yongfang Yuan |
| author_sort | Chunai Gong |
| collection | DOAJ |
| description | Abstract Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specialized cells or hybrid membranes that combine the capacities of different types of cell membranes. Here, hybrid membrane-coated doxorubicin (Dox)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated by fusing membrane components derived from RAW264.7(RAW) and 4T1 cells (4T1). These NPs were used to treat lung metastases originating from breast cancer. This study indicates that the coupling of NPs with a hybrid membrane derived from macrophage and cancer cells has several advantages, such as the tendency to accumulate at sites of inflammation, ability to target specific metastasis, homogenous tumor targeting abilities in vitro, and markedly enhanced multi-target capability in a lung metastasis model in vivo. The DPLGA@[RAW-4T1] NPs exhibited excellent chemotherapeutic potential with approximately 88.9% anti-metastasis efficacy following treatment of breast cancer-derived lung metastases. These NPs were robust and displayed the multi-targeting abilities of hybrid membranes. This study provides a promising biomimetic nanoplatform for effective treatment of breast cancer metastasis. |
| first_indexed | 2024-04-14T01:30:07Z |
| format | Article |
| id | doaj.art-878d51497f4b43ee9106f21c0ea4738c |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T01:30:07Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-878d51497f4b43ee9106f21c0ea4738c2022-12-22T02:20:13ZengBMCJournal of Nanobiotechnology1477-31552020-06-0118111710.1186/s12951-020-00649-8Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapyChunai Gong0Xiaoyan Yu1Benming You2Yan Wu3Rong Wang4Lu Han5Yujie Wang6Shen Gao7Yongfang Yuan8Department of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Pharmaceutics, Changhai Hospital, Second Military Medical UniversityDepartment of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineDepartment of Pharmaceutics, Changhai Hospital, Second Military Medical UniversityDepartment of Pharmacy, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of MedicineAbstract Cell membrane- covered drug-delivery nanoplatforms have been garnering attention because of their enhanced bio-interfacing capabilities that originate from source cells. In this top-down technique, nanoparticles (NPs) are covered by various membrane coatings, including membranes from specialized cells or hybrid membranes that combine the capacities of different types of cell membranes. Here, hybrid membrane-coated doxorubicin (Dox)-loaded poly(lactic-co-glycolic acid) (PLGA) NPs (DPLGA@[RAW-4T1] NPs) were fabricated by fusing membrane components derived from RAW264.7(RAW) and 4T1 cells (4T1). These NPs were used to treat lung metastases originating from breast cancer. This study indicates that the coupling of NPs with a hybrid membrane derived from macrophage and cancer cells has several advantages, such as the tendency to accumulate at sites of inflammation, ability to target specific metastasis, homogenous tumor targeting abilities in vitro, and markedly enhanced multi-target capability in a lung metastasis model in vivo. The DPLGA@[RAW-4T1] NPs exhibited excellent chemotherapeutic potential with approximately 88.9% anti-metastasis efficacy following treatment of breast cancer-derived lung metastases. These NPs were robust and displayed the multi-targeting abilities of hybrid membranes. This study provides a promising biomimetic nanoplatform for effective treatment of breast cancer metastasis.http://link.springer.com/article/10.1186/s12951-020-00649-8Hybrid membraneBiomimetic nanoparticlesMulti-target capabilityMetastasis breast cancerChemotherapy |
| spellingShingle | Chunai Gong Xiaoyan Yu Benming You Yan Wu Rong Wang Lu Han Yujie Wang Shen Gao Yongfang Yuan Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy Journal of Nanobiotechnology Hybrid membrane Biomimetic nanoparticles Multi-target capability Metastasis breast cancer Chemotherapy |
| title | Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy |
| title_full | Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy |
| title_fullStr | Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy |
| title_full_unstemmed | Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy |
| title_short | Macrophage-cancer hybrid membrane-coated nanoparticles for targeting lung metastasis in breast cancer therapy |
| title_sort | macrophage cancer hybrid membrane coated nanoparticles for targeting lung metastasis in breast cancer therapy |
| topic | Hybrid membrane Biomimetic nanoparticles Multi-target capability Metastasis breast cancer Chemotherapy |
| url | http://link.springer.com/article/10.1186/s12951-020-00649-8 |
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