Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature
Meningiomas are the most common primary intracranial tumor thought to derived from arachnoidal cap cells in the meningeal coverings of the spinal cord and brain. The current WHO classification, published in 2016, includes nine different subtypes of grade 1 meningiomas, three different subtypes of g...
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| Format: | Article |
| Language: | English |
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Cukurova University
2021-06-01
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| Series: | Cukurova Medical Journal |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/1445566 |
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| author | Emel Çakır İsmail Saygın İlker Eyüpoğlu |
| author_facet | Emel Çakır İsmail Saygın İlker Eyüpoğlu |
| author_sort | Emel Çakır |
| collection | DOAJ |
| description | Meningiomas are the most common primary intracranial tumor thought to derived from arachnoidal cap cells in the meningeal coverings of the spinal cord and brain. The current WHO classification, published in 2016, includes nine different subtypes of grade 1 meningiomas, three different subtypes of grade 2 meningiomas, and three different subtypes of grade 3 meningiomas. Metaplastic meningioma is a rare variant which shows focal or diffuse mesenchymal tissue component. Xanthomatous meningioma which has foamy cell changes is a quite rare variant of metaplastic meningioma. Two patients, 54 and 59 years old, who applied to our clinic with similar symptoms, were operated for meningioma. Histopathological examination of their biopsy showed that neoplastic cells had oval-round nuclei and eosinophilic cytoplasm. In xanthomatous meningioma, some neoplastic cells had clear vacuolated cytoplasm (foamy cells). In microscopic examination of resection material in one of these patients, cells in some areas of the tumor had clear vacuolated cytoplasm (foamy cells). These neoplastic cells were scattered among other meningothelial cells and they were positive for EMA. To the best of our knowledge, until today there have been only 14 reported xanthomatous meningioma cases in English literature. Here, we aimed to discuss the pathogenesis and differential diagnosis of xanthomatous meningioma in two different cases |
| first_indexed | 2024-04-10T12:41:54Z |
| format | Article |
| id | doaj.art-87911b0fb95d4becaead431dfafda1f1 |
| institution | Directory Open Access Journal |
| issn | 2602-3040 |
| language | English |
| last_indexed | 2024-04-10T12:41:54Z |
| publishDate | 2021-06-01 |
| publisher | Cukurova University |
| record_format | Article |
| series | Cukurova Medical Journal |
| spelling | doaj.art-87911b0fb95d4becaead431dfafda1f12023-02-15T16:14:16ZengCukurova UniversityCukurova Medical Journal2602-30402021-06-0146283483910.17826/cumj.83993248Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literatureEmel Çakır0İsmail Saygın1İlker Eyüpoğlu2KARADENİZ TEKNİK ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALIKARADENİZ TEKNİK ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, TIBBİ PATOLOJİ ANABİLİM DALIKARADENİZ TEKNİK ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, RADYOLOJİ ANABİLİM DALIMeningiomas are the most common primary intracranial tumor thought to derived from arachnoidal cap cells in the meningeal coverings of the spinal cord and brain. The current WHO classification, published in 2016, includes nine different subtypes of grade 1 meningiomas, three different subtypes of grade 2 meningiomas, and three different subtypes of grade 3 meningiomas. Metaplastic meningioma is a rare variant which shows focal or diffuse mesenchymal tissue component. Xanthomatous meningioma which has foamy cell changes is a quite rare variant of metaplastic meningioma. Two patients, 54 and 59 years old, who applied to our clinic with similar symptoms, were operated for meningioma. Histopathological examination of their biopsy showed that neoplastic cells had oval-round nuclei and eosinophilic cytoplasm. In xanthomatous meningioma, some neoplastic cells had clear vacuolated cytoplasm (foamy cells). In microscopic examination of resection material in one of these patients, cells in some areas of the tumor had clear vacuolated cytoplasm (foamy cells). These neoplastic cells were scattered among other meningothelial cells and they were positive for EMA. To the best of our knowledge, until today there have been only 14 reported xanthomatous meningioma cases in English literature. Here, we aimed to discuss the pathogenesis and differential diagnosis of xanthomatous meningioma in two different caseshttps://dergipark.org.tr/tr/download/article-file/1445566foamy cellxanthomatousmetaplastichistiocyticmeningiomaköpüksü hücreksantomatozmetaplastikhistiositikmenengiom |
| spellingShingle | Emel Çakır İsmail Saygın İlker Eyüpoğlu Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature Cukurova Medical Journal foamy cell xanthomatous metaplastic histiocytic meningioma köpüksü hücre ksantomatoz metaplastik histiositik menengiom |
| title | Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature |
| title_full | Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature |
| title_fullStr | Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature |
| title_full_unstemmed | Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature |
| title_short | Two distinct case reports with foamy cell and differential diagnosis: Xanthomatous meningioma and review of literature |
| title_sort | two distinct case reports with foamy cell and differential diagnosis xanthomatous meningioma and review of literature |
| topic | foamy cell xanthomatous metaplastic histiocytic meningioma köpüksü hücre ksantomatoz metaplastik histiositik menengiom |
| url | https://dergipark.org.tr/tr/download/article-file/1445566 |
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