Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years
Objective: To evaluate the predictive value of asymptomatic early house dust mite sensitization on allergic outcomes and pulmonary functions in 7-year olds. Study design: The Prediction of Allergies in Taiwanese Children (PATCH) birth cohort study recruited healthy newborns at birth. At age 1.5–2 ye...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-09-01
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| Series: | World Allergy Organization Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455119312104 |
| _version_ | 1811334391407837184 |
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| author | Kuan-Wen Su Chih-Yung Chiu Ming-Han Tsai Sui-Lin Liao Li-Chen Chen Man-Chin Hua Tsung-Chieh Yao Jing-Long Huang Kuo-Wei Yeh |
| author_facet | Kuan-Wen Su Chih-Yung Chiu Ming-Han Tsai Sui-Lin Liao Li-Chen Chen Man-Chin Hua Tsung-Chieh Yao Jing-Long Huang Kuo-Wei Yeh |
| author_sort | Kuan-Wen Su |
| collection | DOAJ |
| description | Objective: To evaluate the predictive value of asymptomatic early house dust mite sensitization on allergic outcomes and pulmonary functions in 7-year olds. Study design: The Prediction of Allergies in Taiwanese Children (PATCH) birth cohort study recruited healthy newborns at birth. At age 1.5–2 years, a Dermatophagoides pteronyssinus-specific immunoglobulin E level ≥ 0.35 kU/L was defined as early sensitization. At age 7 years, allergic outcomes were evaluated by pediatric allergists and pulmonologists, and fractional exhaled nitric oxide and pulmonary functions were measured. Results: At age 1.5–2 years, 28.0% of toddlers were sensitized to D. pteronyssinus. Among them, 68.2% had no allergic symptoms at that time. At age 7 years, the children with early sensitization had higher risks of asthma (OR = 13.4, 95% CI, 1.2 to 153.0; P = 0.037), allergic rhinitis (OR = 10.2, 95% CI, 2.1 to 49.6; P = 0.004), and atopic dermatitis (OR = 38.5, 95% CI, 2.1 to 696.4; P = 0.014). Notably, even the asymptomatic toddlers with early D. pteronyssinus sensitization had higher probabilities of asthma (12.5% vs. 1.7%, P = 0.040), allergic rhinitis (83.3% vs. 43.1%, P = 0.009), and atopic dermatitis (20.8% vs. 0.0%, P < 0.001) at age 7 years. The asymptomatic toddlers with early sensitization also had higher exhaled nitric oxide levels and higher prevalence of airway hyperresponsiveness at age 7 years. Conclusion: Asymptomatic toddlers with early house dust mite sensitization have higher risks of developing asthma, allergic rhinitis, atopic dermatitis, and abnormal lung functions at age 7 years. Keywords: Birth cohort, House dust mite, Pediatric asthma, Pulmonary function |
| first_indexed | 2024-04-13T17:07:09Z |
| format | Article |
| id | doaj.art-87921f2b4e884474a16b2b2955e13fb5 |
| institution | Directory Open Access Journal |
| issn | 1939-4551 |
| language | English |
| last_indexed | 2024-04-13T17:07:09Z |
| publishDate | 2019-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj.art-87921f2b4e884474a16b2b2955e13fb52022-12-22T02:38:25ZengElsevierWorld Allergy Organization Journal1939-45512019-09-01129Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 yearsKuan-Wen Su0Chih-Yung Chiu1Ming-Han Tsai2Sui-Lin Liao3Li-Chen Chen4Man-Chin Hua5Tsung-Chieh Yao6Jing-Long Huang7Kuo-Wei Yeh8Department of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Graduate Institute of Clinical Medical Science, Chang Gung University College of Medicine, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Division of Pediatric Pulmonology, College of Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, TaiwanDepartment of Pediatrics, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Community Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Hsin Street, Kweishan, Taoyuan, 333, TaiwanCommunity Medicine Research Center, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Corresponding author. Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University, No. 5, Fu-Hsin Street, Kweishan, Taoyuan, 333, TaiwanObjective: To evaluate the predictive value of asymptomatic early house dust mite sensitization on allergic outcomes and pulmonary functions in 7-year olds. Study design: The Prediction of Allergies in Taiwanese Children (PATCH) birth cohort study recruited healthy newborns at birth. At age 1.5–2 years, a Dermatophagoides pteronyssinus-specific immunoglobulin E level ≥ 0.35 kU/L was defined as early sensitization. At age 7 years, allergic outcomes were evaluated by pediatric allergists and pulmonologists, and fractional exhaled nitric oxide and pulmonary functions were measured. Results: At age 1.5–2 years, 28.0% of toddlers were sensitized to D. pteronyssinus. Among them, 68.2% had no allergic symptoms at that time. At age 7 years, the children with early sensitization had higher risks of asthma (OR = 13.4, 95% CI, 1.2 to 153.0; P = 0.037), allergic rhinitis (OR = 10.2, 95% CI, 2.1 to 49.6; P = 0.004), and atopic dermatitis (OR = 38.5, 95% CI, 2.1 to 696.4; P = 0.014). Notably, even the asymptomatic toddlers with early D. pteronyssinus sensitization had higher probabilities of asthma (12.5% vs. 1.7%, P = 0.040), allergic rhinitis (83.3% vs. 43.1%, P = 0.009), and atopic dermatitis (20.8% vs. 0.0%, P < 0.001) at age 7 years. The asymptomatic toddlers with early sensitization also had higher exhaled nitric oxide levels and higher prevalence of airway hyperresponsiveness at age 7 years. Conclusion: Asymptomatic toddlers with early house dust mite sensitization have higher risks of developing asthma, allergic rhinitis, atopic dermatitis, and abnormal lung functions at age 7 years. Keywords: Birth cohort, House dust mite, Pediatric asthma, Pulmonary functionhttp://www.sciencedirect.com/science/article/pii/S1939455119312104 |
| spellingShingle | Kuan-Wen Su Chih-Yung Chiu Ming-Han Tsai Sui-Lin Liao Li-Chen Chen Man-Chin Hua Tsung-Chieh Yao Jing-Long Huang Kuo-Wei Yeh Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years World Allergy Organization Journal |
| title | Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years |
| title_full | Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years |
| title_fullStr | Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years |
| title_full_unstemmed | Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years |
| title_short | Asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years |
| title_sort | asymptomatic toddlers with house dust mite sensitization at risk of asthma and abnormal lung functions at age 7 years |
| url | http://www.sciencedirect.com/science/article/pii/S1939455119312104 |
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