Bacteriocins in the Era of Antibiotic Resistance: Rising to the Challenge
Decades of antibiotic misuse in clinical settings, animal feed, and within the food industry have led to a concerning rise in antibiotic-resistant bacteria. Every year, antimicrobial-resistant infections cause 700,000 deaths, with 10 million casualties expected by 2050, if this trend continues. Henc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/2/196 |
| _version_ | 1797416661032108032 |
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| author | Gratiela Gradisteanu Pircalabioru Laura Ioana Popa Luminita Marutescu Irina Gheorghe Marcela Popa Ilda Czobor Barbu Rodica Cristescu Mariana-Carmen Chifiriuc |
| author_facet | Gratiela Gradisteanu Pircalabioru Laura Ioana Popa Luminita Marutescu Irina Gheorghe Marcela Popa Ilda Czobor Barbu Rodica Cristescu Mariana-Carmen Chifiriuc |
| author_sort | Gratiela Gradisteanu Pircalabioru |
| collection | DOAJ |
| description | Decades of antibiotic misuse in clinical settings, animal feed, and within the food industry have led to a concerning rise in antibiotic-resistant bacteria. Every year, antimicrobial-resistant infections cause 700,000 deaths, with 10 million casualties expected by 2050, if this trend continues. Hence, innovative solutions are imperative to curb antibiotic resistance. Bacteria produce a potent arsenal of drugs with remarkable diversity that are all distinct from those of current antibiotics. Bacteriocins are potent small antimicrobial peptides synthetized by certain bacteria that may be appointed as alternatives to traditional antibiotics. These molecules are strategically employed by commensals, mostly Firmicutes, to colonize and persist in the human gut. Bacteriocins form channels in the target cell membrane, leading to leakage of low-molecular-weight, causing the disruption of the proton motive force. The objective of this review was to list and discuss the potential of bacteriocins as antimicrobial therapeutics for infections produced mainly by resistant pathogens. |
| first_indexed | 2024-03-09T06:06:26Z |
| format | Article |
| id | doaj.art-8792f46da1cc432083bddda03156451f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T06:06:26Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8792f46da1cc432083bddda03156451f2023-12-03T12:02:40ZengMDPI AGPharmaceutics1999-49232021-02-0113219610.3390/pharmaceutics13020196Bacteriocins in the Era of Antibiotic Resistance: Rising to the ChallengeGratiela Gradisteanu Pircalabioru0Laura Ioana Popa1Luminita Marutescu2Irina Gheorghe3Marcela Popa4Ilda Czobor Barbu5Rodica Cristescu6Mariana-Carmen Chifiriuc7Research Institute of the University of Bucharest, Earth, Environmental and Life Sciences, Section-ICUB, 050663 Bucharest, RomaniaResearch Institute of the University of Bucharest, Earth, Environmental and Life Sciences, Section-ICUB, 050663 Bucharest, RomaniaResearch Institute of the University of Bucharest, Earth, Environmental and Life Sciences, Section-ICUB, 050663 Bucharest, RomaniaResearch Institute of the University of Bucharest, Earth, Environmental and Life Sciences, Section-ICUB, 050663 Bucharest, RomaniaResearch Institute of the University of Bucharest, Earth, Environmental and Life Sciences, Section-ICUB, 050663 Bucharest, RomaniaResearch Institute of the University of Bucharest, Earth, Environmental and Life Sciences, Section-ICUB, 050663 Bucharest, RomaniaLasers Department, National Institute for Lasers, Plasma and Radiation Physics, P.O. Box MG-36, RO-077125 Magurele, RomaniaResearch Institute of the University of Bucharest, Earth, Environmental and Life Sciences, Section-ICUB, 050663 Bucharest, RomaniaDecades of antibiotic misuse in clinical settings, animal feed, and within the food industry have led to a concerning rise in antibiotic-resistant bacteria. Every year, antimicrobial-resistant infections cause 700,000 deaths, with 10 million casualties expected by 2050, if this trend continues. Hence, innovative solutions are imperative to curb antibiotic resistance. Bacteria produce a potent arsenal of drugs with remarkable diversity that are all distinct from those of current antibiotics. Bacteriocins are potent small antimicrobial peptides synthetized by certain bacteria that may be appointed as alternatives to traditional antibiotics. These molecules are strategically employed by commensals, mostly Firmicutes, to colonize and persist in the human gut. Bacteriocins form channels in the target cell membrane, leading to leakage of low-molecular-weight, causing the disruption of the proton motive force. The objective of this review was to list and discuss the potential of bacteriocins as antimicrobial therapeutics for infections produced mainly by resistant pathogens.https://www.mdpi.com/1999-4923/13/2/196bacteriocinsnisinantibiotic resistance |
| spellingShingle | Gratiela Gradisteanu Pircalabioru Laura Ioana Popa Luminita Marutescu Irina Gheorghe Marcela Popa Ilda Czobor Barbu Rodica Cristescu Mariana-Carmen Chifiriuc Bacteriocins in the Era of Antibiotic Resistance: Rising to the Challenge Pharmaceutics bacteriocins nisin antibiotic resistance |
| title | Bacteriocins in the Era of Antibiotic Resistance: Rising to the Challenge |
| title_full | Bacteriocins in the Era of Antibiotic Resistance: Rising to the Challenge |
| title_fullStr | Bacteriocins in the Era of Antibiotic Resistance: Rising to the Challenge |
| title_full_unstemmed | Bacteriocins in the Era of Antibiotic Resistance: Rising to the Challenge |
| title_short | Bacteriocins in the Era of Antibiotic Resistance: Rising to the Challenge |
| title_sort | bacteriocins in the era of antibiotic resistance rising to the challenge |
| topic | bacteriocins nisin antibiotic resistance |
| url | https://www.mdpi.com/1999-4923/13/2/196 |
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