The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study
Abstract Background Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response to treatment. The influence of white blood cell (WBC) subtype counts on...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-022-00900-y |
| _version_ | 1811203978785980416 |
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| author | Guo-Qiang Pan Chun-Cheng Yang Xiao-ling Shang Zhao-Ru Dong Tao Li |
| author_facet | Guo-Qiang Pan Chun-Cheng Yang Xiao-ling Shang Zhao-Ru Dong Tao Li |
| author_sort | Guo-Qiang Pan |
| collection | DOAJ |
| description | Abstract Background Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response to treatment. The influence of white blood cell (WBC) subtype counts on HCC progression remains unclear. Methods In this study, we performed a Mendelian randomization (MR) study with the validation of two datasets. The summary data for WBC counts were extracted from a recent large GWAS of individuals of European ancestry. The GWAS data related to HCC were obtained from the UK Biobank (UKB). Univariable and multivariable MR analyses were used to identify risk factors genetically associated with HCC risks. Results In the discovery dataset, multivariable MR analysis revealed that sum basophil neutrophil counts had an independent causal effect on the occurrence of HCC, with the sum basophil neutrophil counts as follows: (OR = 0.437, P = 0.003, CI 0.252–0.757). Similarly, in the validation dataset, total basophil neutrophil counts were also been identified as an independent risk factor for HCC. The sum basophil neutrophil counts were as follows: (OR = 0.574, P = 0.021, CI 0.358–0.920). Conclusion In the European population, genetically predicted lower total basophil neutrophil counts might be an independent risk factor for HCC. |
| first_indexed | 2024-04-12T03:05:01Z |
| format | Article |
| id | doaj.art-87946c1a269544698629ed4ec5a077ce |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-12T03:05:01Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-87946c1a269544698629ed4ec5a077ce2022-12-22T03:50:32ZengBMCEuropean Journal of Medical Research2047-783X2022-12-0127111010.1186/s40001-022-00900-yThe causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization studyGuo-Qiang Pan0Chun-Cheng Yang1Xiao-ling Shang2Zhao-Ru Dong3Tao Li4Department of General Surgery, Qilu Hospital, Shandong UniversityDepartment of General Surgery, Qilu Hospital, Shandong UniversityDepartment of Medical Oncology, Qilu Hospital, Shandong UniversityDepartment of General Surgery, Qilu Hospital, Shandong UniversityDepartment of Hepatobiliary Surgery, The Second Hospital of Shandong UniversityAbstract Background Most of hepatocellular carcinoma (HCC) arises on the background of chronic inflammation. The presence of infiltrating inflammatory cells is associated with tumour initiation, progression and clinical response to treatment. The influence of white blood cell (WBC) subtype counts on HCC progression remains unclear. Methods In this study, we performed a Mendelian randomization (MR) study with the validation of two datasets. The summary data for WBC counts were extracted from a recent large GWAS of individuals of European ancestry. The GWAS data related to HCC were obtained from the UK Biobank (UKB). Univariable and multivariable MR analyses were used to identify risk factors genetically associated with HCC risks. Results In the discovery dataset, multivariable MR analysis revealed that sum basophil neutrophil counts had an independent causal effect on the occurrence of HCC, with the sum basophil neutrophil counts as follows: (OR = 0.437, P = 0.003, CI 0.252–0.757). Similarly, in the validation dataset, total basophil neutrophil counts were also been identified as an independent risk factor for HCC. The sum basophil neutrophil counts were as follows: (OR = 0.574, P = 0.021, CI 0.358–0.920). Conclusion In the European population, genetically predicted lower total basophil neutrophil counts might be an independent risk factor for HCC.https://doi.org/10.1186/s40001-022-00900-yHCCWhite blood cellsMendelian randomization studyCausal relationship |
| spellingShingle | Guo-Qiang Pan Chun-Cheng Yang Xiao-ling Shang Zhao-Ru Dong Tao Li The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study European Journal of Medical Research HCC White blood cells Mendelian randomization study Causal relationship |
| title | The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study |
| title_full | The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study |
| title_fullStr | The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study |
| title_full_unstemmed | The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study |
| title_short | The causal relationship between white blood cell counts and hepatocellular carcinoma: a Mendelian randomization study |
| title_sort | causal relationship between white blood cell counts and hepatocellular carcinoma a mendelian randomization study |
| topic | HCC White blood cells Mendelian randomization study Causal relationship |
| url | https://doi.org/10.1186/s40001-022-00900-y |
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