Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents
IntroductionChildhood obesity presents a major risk for metabolic diseases in adulthood. Noninvasive methods are needed for predicting the course of obesity in children and its complications. Using blood for longitudinal analyses of biomarkers to predict disease in children is not a convenient metho...
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Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.800373/full |
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| author | Hend Alqaderi Hend Alqaderi Hend Alqaderi Fahad Hegazi Fahd Al-Mulla Chung-Jung Chiu Alpdogan Kantarci Ebaa Al-Ozairi Ebaa Al-Ozairi Mohamed Abu-Farha Saadoun Bin-Hasan Saadoun Bin-Hasan Aishah Alsumait Jehad Abubaker Sriraman Devarajan J. Max Goodson Hatice Hasturk Mary Tavares Mary Tavares Mary Tavares |
| author_facet | Hend Alqaderi Hend Alqaderi Hend Alqaderi Fahad Hegazi Fahd Al-Mulla Chung-Jung Chiu Alpdogan Kantarci Ebaa Al-Ozairi Ebaa Al-Ozairi Mohamed Abu-Farha Saadoun Bin-Hasan Saadoun Bin-Hasan Aishah Alsumait Jehad Abubaker Sriraman Devarajan J. Max Goodson Hatice Hasturk Mary Tavares Mary Tavares Mary Tavares |
| author_sort | Hend Alqaderi |
| collection | DOAJ |
| description | IntroductionChildhood obesity presents a major risk for metabolic diseases in adulthood. Noninvasive methods are needed for predicting the course of obesity in children and its complications. Using blood for longitudinal analyses of biomarkers to predict disease in children is not a convenient method. Saliva presents a noninvasive platform to detect inflammatory changes in biomarkers as possible predictive measures of future pathological events.ObjectivesThe aim of this study was to evaluate the relationship between specific salivary biomarkers, obesity, and intermediate hyperglycemia in children. We also investigated the longitudinal association between the salivary biomarkers and change in Body Mass Index-for-age percentile scores (BMIz).MethodsData on 353 adolescents were collected from the individuals recruited for seven years in an ongoing Kuwait Healthy Life Study cohort. BMIz was measured at 10, 12, and 17 years of age. Interleukin (IL)-6, IL-8, IL-10, Leptin, C-Reactive Protein (CRP), Insulin, Vascular Endothelial Growth Factor (VEGF), and Monocyte Chemoattractant Protein-1 (MCP-1) were measured in saliva and serum. Additionally, fasting blood plasma glucose levels were recorded. Multilevel longitudinal regression modeling, mediation analyses, and logistic regression were used to determine the predictive value of salivary biomarkers in obesity and hyperglycemia.ResultsLongitudinal analyses showed that with each one-unit increase of salivary CRP and insulin, there was a 3.5 kg/m2 and 3.2 kg/m2 increase in BMIz, respectively. Comparable to serum CRP and insulin, higher salivary CRP and insulin OR 4.94 [95%CI: 1.66,14., OR 2.64 [95%CI: 1.09, 6.38], respectively) were predictive of hyperglycemia and obesity (OR 4.53 [95%CI: 2.40,8.50], OR 3.29 [95%CI: 1.82,5.97], respectively). Insulin was a strong mediator in the relationship between obesity and hyperglycemia.ConclusionOur findings demonstrated that salivary CRP and insulin were associated with hyperglycemia, obesity, and possibly diabetes in adolescents. Salivary biomarkers are a noninvasive approach with significant value for disease risk assessment and prevention. |
| first_indexed | 2024-12-12T03:13:13Z |
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| language | English |
| last_indexed | 2024-12-12T03:13:13Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-8796e1c6670e41faa5b225bd0e13293a2022-12-22T00:40:21ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-06-011010.3389/fpubh.2022.800373800373Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in AdolescentsHend Alqaderi0Hend Alqaderi1Hend Alqaderi2Fahad Hegazi3Fahd Al-Mulla4Chung-Jung Chiu5Alpdogan Kantarci6Ebaa Al-Ozairi7Ebaa Al-Ozairi8Mohamed Abu-Farha9Saadoun Bin-Hasan10Saadoun Bin-Hasan11Aishah Alsumait12Jehad Abubaker13Sriraman Devarajan14J. Max Goodson15Hatice Hasturk16Mary Tavares17Mary Tavares18Mary Tavares19Department of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitKuwait School Oral Health Program, Ministry of Health, Kuwait City, KuwaitDepartment of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, United StatesDepartment of Preventive Dental Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi ArabiaDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitCenter for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United StatesCenter for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United StatesDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Medicine, Faculty of Medicine, Kuwait University, Kuwait City, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitFarwaniya Hospital, Ministry of Health, Sabah Al Nasser, KuwaitKuwait School Oral Health Program, Ministry of Health, Kuwait City, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitDepartment of Biochemistry and Molecular Biology, Dasman Diabetes Institute, Kuwait City, KuwaitCenter for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United StatesCenter for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United StatesDepartment of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, United StatesCenter for Clinical and Translational Research, The Forsyth Institute, Cambridge, MA, United StatesDepartment of Health Policy and Health Services Research, Boston University Henry M. Goldman School of Dental Medicine, Boston, MA, United StatesIntroductionChildhood obesity presents a major risk for metabolic diseases in adulthood. Noninvasive methods are needed for predicting the course of obesity in children and its complications. Using blood for longitudinal analyses of biomarkers to predict disease in children is not a convenient method. Saliva presents a noninvasive platform to detect inflammatory changes in biomarkers as possible predictive measures of future pathological events.ObjectivesThe aim of this study was to evaluate the relationship between specific salivary biomarkers, obesity, and intermediate hyperglycemia in children. We also investigated the longitudinal association between the salivary biomarkers and change in Body Mass Index-for-age percentile scores (BMIz).MethodsData on 353 adolescents were collected from the individuals recruited for seven years in an ongoing Kuwait Healthy Life Study cohort. BMIz was measured at 10, 12, and 17 years of age. Interleukin (IL)-6, IL-8, IL-10, Leptin, C-Reactive Protein (CRP), Insulin, Vascular Endothelial Growth Factor (VEGF), and Monocyte Chemoattractant Protein-1 (MCP-1) were measured in saliva and serum. Additionally, fasting blood plasma glucose levels were recorded. Multilevel longitudinal regression modeling, mediation analyses, and logistic regression were used to determine the predictive value of salivary biomarkers in obesity and hyperglycemia.ResultsLongitudinal analyses showed that with each one-unit increase of salivary CRP and insulin, there was a 3.5 kg/m2 and 3.2 kg/m2 increase in BMIz, respectively. Comparable to serum CRP and insulin, higher salivary CRP and insulin OR 4.94 [95%CI: 1.66,14., OR 2.64 [95%CI: 1.09, 6.38], respectively) were predictive of hyperglycemia and obesity (OR 4.53 [95%CI: 2.40,8.50], OR 3.29 [95%CI: 1.82,5.97], respectively). Insulin was a strong mediator in the relationship between obesity and hyperglycemia.ConclusionOur findings demonstrated that salivary CRP and insulin were associated with hyperglycemia, obesity, and possibly diabetes in adolescents. Salivary biomarkers are a noninvasive approach with significant value for disease risk assessment and prevention.https://www.frontiersin.org/articles/10.3389/fpubh.2022.800373/fullinflammationsalivametabolic diseasecytokineschildrenobesity |
| spellingShingle | Hend Alqaderi Hend Alqaderi Hend Alqaderi Fahad Hegazi Fahd Al-Mulla Chung-Jung Chiu Alpdogan Kantarci Ebaa Al-Ozairi Ebaa Al-Ozairi Mohamed Abu-Farha Saadoun Bin-Hasan Saadoun Bin-Hasan Aishah Alsumait Jehad Abubaker Sriraman Devarajan J. Max Goodson Hatice Hasturk Mary Tavares Mary Tavares Mary Tavares Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents Frontiers in Public Health inflammation saliva metabolic disease cytokines children obesity |
| title | Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents |
| title_full | Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents |
| title_fullStr | Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents |
| title_full_unstemmed | Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents |
| title_short | Salivary Biomarkers as Predictors of Obesity and Intermediate Hyperglycemia in Adolescents |
| title_sort | salivary biomarkers as predictors of obesity and intermediate hyperglycemia in adolescents |
| topic | inflammation saliva metabolic disease cytokines children obesity |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.800373/full |
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