Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysis
Abstract Background Liver resection is the first-line treatment for patients with resectable colorectal liver metastasis (CRLM), while radiofrequency ablation (RFA) can be used for small unresectable CRLM because of disease extent, poor anatomical location, or comorbidities. However, the long-term o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12957-018-1494-3 |
| _version_ | 1818135689430040576 |
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| author | Li-Jun Wang Zhong-Yi Zhang Xiao-Luan Yan Wei Yang Kun Yan Bao-Cai Xing |
| author_facet | Li-Jun Wang Zhong-Yi Zhang Xiao-Luan Yan Wei Yang Kun Yan Bao-Cai Xing |
| author_sort | Li-Jun Wang |
| collection | DOAJ |
| description | Abstract Background Liver resection is the first-line treatment for patients with resectable colorectal liver metastasis (CRLM), while radiofrequency ablation (RFA) can be used for small unresectable CRLM because of disease extent, poor anatomical location, or comorbidities. However, the long-term outcomes are unclear for RFA treatment in resectable CRLM. This study aimed to compare the recurrence rates and prognosis between resectable CRLM patients receiving either liver resection or RFA. Methods Consecutive patients who underwent RFA or hepatic resection from November 2010 to December 2015 were assigned in this retrospective study. Propensity score analysis was used to eliminate baseline differences between groups. Survival and recurrence rates were compared between patients receiving liver resection and RFA. Results With 1:2 ratio of propensity scoring, 46 patients in the RFA group and 92 in the resection group were successfully matched. Overall survival was similar between the two groups, but the resection group had a higher disease-free survival (median, 22 months vs. 14 months). Whereas among patients with a tumor size of ≤ 3 cm, disease-free survival was similar in the two groups (median, 24 months vs. 21 months). Compared to the resection group, the RFA group had a higher rate of intrahepatic recurrence (34.8% vs. 12.0%) and a shorter recurrence free period. The local and systemic recurrence rate and recurrence-free period for the same were insignificant in the two groups. Poor disease-free survival was associated with RFA, T4, tumor diameter > 3 cm, and lymph node positivity. Conclusion Among patients with technically resectable CRLM, resection provided greater disease-free survival, although both treatment modalities provided similar overall survival. |
| first_indexed | 2024-12-11T09:28:30Z |
| format | Article |
| id | doaj.art-879700cb041b4cfaa221d61e19297445 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-11T09:28:30Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-879700cb041b4cfaa221d61e192974452022-12-22T01:13:04ZengBMCWorld Journal of Surgical Oncology1477-78192018-10-011611810.1186/s12957-018-1494-3Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysisLi-Jun Wang0Zhong-Yi Zhang1Xiao-Luan Yan2Wei Yang3Kun Yan4Bao-Cai Xing5Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepatopancreatobiliary Surgery Unit I, Peking University Cancer Hospital and InstituteKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound, Peking University Cancer Hospital and InstituteKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepatopancreatobiliary Surgery Unit I, Peking University Cancer Hospital and InstituteKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound, Peking University Cancer Hospital and InstituteKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Ultrasound, Peking University Cancer Hospital and InstituteKey laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Hepatopancreatobiliary Surgery Unit I, Peking University Cancer Hospital and InstituteAbstract Background Liver resection is the first-line treatment for patients with resectable colorectal liver metastasis (CRLM), while radiofrequency ablation (RFA) can be used for small unresectable CRLM because of disease extent, poor anatomical location, or comorbidities. However, the long-term outcomes are unclear for RFA treatment in resectable CRLM. This study aimed to compare the recurrence rates and prognosis between resectable CRLM patients receiving either liver resection or RFA. Methods Consecutive patients who underwent RFA or hepatic resection from November 2010 to December 2015 were assigned in this retrospective study. Propensity score analysis was used to eliminate baseline differences between groups. Survival and recurrence rates were compared between patients receiving liver resection and RFA. Results With 1:2 ratio of propensity scoring, 46 patients in the RFA group and 92 in the resection group were successfully matched. Overall survival was similar between the two groups, but the resection group had a higher disease-free survival (median, 22 months vs. 14 months). Whereas among patients with a tumor size of ≤ 3 cm, disease-free survival was similar in the two groups (median, 24 months vs. 21 months). Compared to the resection group, the RFA group had a higher rate of intrahepatic recurrence (34.8% vs. 12.0%) and a shorter recurrence free period. The local and systemic recurrence rate and recurrence-free period for the same were insignificant in the two groups. Poor disease-free survival was associated with RFA, T4, tumor diameter > 3 cm, and lymph node positivity. Conclusion Among patients with technically resectable CRLM, resection provided greater disease-free survival, although both treatment modalities provided similar overall survival.http://link.springer.com/article/10.1186/s12957-018-1494-3Radiofrequency ablationResectionLiver metastasisColorectal cancerSurvival |
| spellingShingle | Li-Jun Wang Zhong-Yi Zhang Xiao-Luan Yan Wei Yang Kun Yan Bao-Cai Xing Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysis World Journal of Surgical Oncology Radiofrequency ablation Resection Liver metastasis Colorectal cancer Survival |
| title | Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysis |
| title_full | Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysis |
| title_fullStr | Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysis |
| title_full_unstemmed | Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysis |
| title_short | Radiofrequency ablation versus resection for technically resectable colorectal liver metastasis: a propensity score analysis |
| title_sort | radiofrequency ablation versus resection for technically resectable colorectal liver metastasis a propensity score analysis |
| topic | Radiofrequency ablation Resection Liver metastasis Colorectal cancer Survival |
| url | http://link.springer.com/article/10.1186/s12957-018-1494-3 |
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