PKG II secreted via the classical endoplasmic reticulum–Golgi apparatus secretory pathway blocks the activation of EGFR through phosporalting its threonine 406 and has an anti-tumor effect

PKG II secreted via the classical endoplasmic reticulum–Golgi apparatus secretory pathway blocks the activation of EGFR through phosporalting its threonine 406 and has an anti-tumor effect

Background: Protein kinase G type II (PKG II) is a serine/threonine-protein kinase that was originally isolated from the small intestinal mucosa with primary functions in the secretion of small intestinal mucosal cells, secretion of renin and aldosterone, and chondrocyte activities. Recent studies h...

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Bibliographic Details
Main Authors: Yan Wu, Min Wu, Zibin Wang, Ji Pang, Miaolin Zhu, Ting Lan, Xiaoyuan Yao, Hai Qian, Xinyue Lin, Lu Jiang, Yan Tao, Yujie Zhang, Yongchang Chen
Format: Article
Language:English
Published: IMR Press 2022-02-01
Series:Frontiers in Bioscience-Landmark
Subjects:
enterochromaffin cells
protein kinase g type ii
protein secretion
epidermal growth factor receptor
threonine 406
Online Access:https://www.imrpress.com/journal/FBL/27/2/10.31083/j.fbl2702053

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