Modeling genetic epileptic encephalopathies using brain organoids

Modeling genetic epileptic encephalopathies using brain organoids

Abstract Developmental and epileptic encephalopathies (DEE) are a group of disorders associated with intractable seizures, brain development, and functional abnormalities, and in some cases, premature death. Pathogenic human germline biallelic mutations in tumor suppressor WW domain‐containing oxido...

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Bibliographic Details
Main Authors: Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab, Ehud Banne, Muhammad Mahajnah, Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan
Format: Article
Language:English
Published: Springer Nature 2021-08-01
Series:EMBO Molecular Medicine
Subjects:
cerebral organoids
DNA damage
SCAR12
Wnt pathway
WOREE syndrome
Online Access:https://doi.org/10.15252/emmm.202013610

Internet

https://doi.org/10.15252/emmm.202013610

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