Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrence
Abstract Introduction Pseudomonas aeruginosa respiratory infections are challenging, and the risk of recurrence is a frequent problem. The aim of this study was to investigate the risk factors associated with the presence of P. aeruginosa, and the risk factors related to the recurrence and death of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-05-01
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| Series: | The Clinical Respiratory Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/crj.13612 |
| _version_ | 1797818854470057984 |
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| author | Larissa Hermann deSouza Nunes João Felipe Bernardi Lora Luiz Augusto Fanhani Cracco Janice Alexandra daCosta Manuel June Alisson Westarb Cruz Joao Paulo Telles Felipe Francisco Tuon |
| author_facet | Larissa Hermann deSouza Nunes João Felipe Bernardi Lora Luiz Augusto Fanhani Cracco Janice Alexandra daCosta Manuel June Alisson Westarb Cruz Joao Paulo Telles Felipe Francisco Tuon |
| author_sort | Larissa Hermann deSouza Nunes |
| collection | DOAJ |
| description | Abstract Introduction Pseudomonas aeruginosa respiratory infections are challenging, and the risk of recurrence is a frequent problem. The aim of this study was to investigate the risk factors associated with the presence of P. aeruginosa, and the risk factors related to the recurrence and death of lower airway infections in inpatients in a Brazilian hospital. Methods Retrospective cohort with inpatients that had a sample of airways culture (tracheal aspirate or bronchoalveolar lavage) with the detection of P. aeruginosa. The patients with clinical criteria of infection were classified as ventilator‐associated, hospital‐acquired, or community‐acquired pneumonia. P. aeruginosa in respiratory samples without symptoms was considered colonization. The antimicrobial treatment adequacy and the clinical data were evaluated. Outcome variables included mortality and recurrence. Results One hundred and fifty‐four patients were included in the study, most of them were men, and the majority (102) were considered infected. The average length of stay was superior to 30 days. Previous pulmonary disease was associated with the occurrence of colonization. Aminoglycosides were the most active drug according to susceptibility tests and were successfully used as monotherapy. Septic shock was a risk factor for death in the infected patients. The use of adequate antimicrobial therapy was associated with major survival, independent of the infection classification. Conclusion It is possible to evaluate clinical data associated with recurrence and mortality in patients with different lung infections by P. aeruginosa. Aminoglycoside monotherapy is safe and effective in P. aeruginosa respiratory infections. |
| first_indexed | 2024-03-13T09:15:16Z |
| format | Article |
| id | doaj.art-8797ab25de3a4eaaa4b3140435213e80 |
| institution | Directory Open Access Journal |
| issn | 1752-6981 1752-699X |
| language | English |
| last_indexed | 2024-03-13T09:15:16Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Clinical Respiratory Journal |
| spelling | doaj.art-8797ab25de3a4eaaa4b3140435213e802023-05-26T10:50:31ZengWileyThe Clinical Respiratory Journal1752-69811752-699X2023-05-0117543944610.1111/crj.13612Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrenceLarissa Hermann deSouza Nunes0João Felipe Bernardi Lora1Luiz Augusto Fanhani Cracco2Janice Alexandra daCosta Manuel3June Alisson Westarb Cruz4Joao Paulo Telles5Felipe Francisco Tuon6Laboratory of Emerging Infectious Diseases, School of Medicine Pontifícia Universidade Católica do Paraná Curitiba Paraná BrazilLaboratory of Emerging Infectious Diseases, School of Medicine Pontifícia Universidade Católica do Paraná Curitiba Paraná BrazilLaboratory of Emerging Infectious Diseases, School of Medicine Pontifícia Universidade Católica do Paraná Curitiba Paraná BrazilAcademia BAI Luanda AngolaPontifícia Universidade Católica do Paraná Curitiba Paraná BrazilLaboratory of Emerging Infectious Diseases, School of Medicine Pontifícia Universidade Católica do Paraná Curitiba Paraná BrazilLaboratory of Emerging Infectious Diseases, School of Medicine Pontifícia Universidade Católica do Paraná Curitiba Paraná BrazilAbstract Introduction Pseudomonas aeruginosa respiratory infections are challenging, and the risk of recurrence is a frequent problem. The aim of this study was to investigate the risk factors associated with the presence of P. aeruginosa, and the risk factors related to the recurrence and death of lower airway infections in inpatients in a Brazilian hospital. Methods Retrospective cohort with inpatients that had a sample of airways culture (tracheal aspirate or bronchoalveolar lavage) with the detection of P. aeruginosa. The patients with clinical criteria of infection were classified as ventilator‐associated, hospital‐acquired, or community‐acquired pneumonia. P. aeruginosa in respiratory samples without symptoms was considered colonization. The antimicrobial treatment adequacy and the clinical data were evaluated. Outcome variables included mortality and recurrence. Results One hundred and fifty‐four patients were included in the study, most of them were men, and the majority (102) were considered infected. The average length of stay was superior to 30 days. Previous pulmonary disease was associated with the occurrence of colonization. Aminoglycosides were the most active drug according to susceptibility tests and were successfully used as monotherapy. Septic shock was a risk factor for death in the infected patients. The use of adequate antimicrobial therapy was associated with major survival, independent of the infection classification. Conclusion It is possible to evaluate clinical data associated with recurrence and mortality in patients with different lung infections by P. aeruginosa. Aminoglycoside monotherapy is safe and effective in P. aeruginosa respiratory infections.https://doi.org/10.1111/crj.13612drug resistanceP. aeruginosarisk factorsventilator‐associated pneumonia |
| spellingShingle | Larissa Hermann deSouza Nunes João Felipe Bernardi Lora Luiz Augusto Fanhani Cracco Janice Alexandra daCosta Manuel June Alisson Westarb Cruz Joao Paulo Telles Felipe Francisco Tuon Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrence The Clinical Respiratory Journal drug resistance P. aeruginosa risk factors ventilator‐associated pneumonia |
| title | Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrence |
| title_full | Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrence |
| title_fullStr | Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrence |
| title_full_unstemmed | Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrence |
| title_short | Pseudomonas aeruginosa in tracheal aspirate: Colonization, infection, and recurrence |
| title_sort | pseudomonas aeruginosa in tracheal aspirate colonization infection and recurrence |
| topic | drug resistance P. aeruginosa risk factors ventilator‐associated pneumonia |
| url | https://doi.org/10.1111/crj.13612 |
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