Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case report
Abstract Background Cranial nerve involvement is not commonly encountered in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP); this is especially true for involvement of the hypoglossal nerve. Neither Beevor's sign nor its inverted form has previously been described in CIDP. Cas...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02287-5 |
| _version_ | 1819144719652880384 |
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| author | Huajian Zhao Yiming Zheng Lingchao Meng Meng Yu Wei Zhang He Lv Zhaoxia Wang Hongjun Hao Yun Yuan |
| author_facet | Huajian Zhao Yiming Zheng Lingchao Meng Meng Yu Wei Zhang He Lv Zhaoxia Wang Hongjun Hao Yun Yuan |
| author_sort | Huajian Zhao |
| collection | DOAJ |
| description | Abstract Background Cranial nerve involvement is not commonly encountered in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP); this is especially true for involvement of the hypoglossal nerve. Neither Beevor's sign nor its inverted form has previously been described in CIDP. Case presentation A 28-year-old man presented with distal-predominant limb weakness and numbness at the age of 18. A diagnosis of CIDP was made, which was confirmed by electrodiagnostic evidence of demyelination. He responded well to intravenous immunoglobulin and glucocorticoid treatment and achieved remission for 5 years. However, the same symptoms relapsed at the age of 28 and lasted for 10 months. On examination, in addition to limb sensory impairment and muscle weakness, mild bilateral facial paresis, tongue atrophy and fasciculations, and inverted Beevor's sign were also observed. A brief literature review of cranial nerve involvements in CIDP and Beevor's sign or its inverted form were also performed. Conclusions Cranial nerves may be affected in patients with CIDP. Facial palsy is most frequently present, while hypoglossal nerve involvement is rare. Inverted Beevor's sign can appear in CIDP patients. |
| first_indexed | 2024-12-22T12:46:36Z |
| format | Article |
| id | doaj.art-8799f590cb834b28b33b6983fa3c8057 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-22T12:46:36Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-8799f590cb834b28b33b6983fa3c80572022-12-21T18:25:19ZengBMCBMC Neurology1471-23772021-06-012111510.1186/s12883-021-02287-5Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case reportHuajian Zhao0Yiming Zheng1Lingchao Meng2Meng Yu3Wei Zhang4He Lv5Zhaoxia Wang6Hongjun Hao7Yun Yuan8Neurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalNeurology Department, Peking University First HospitalAbstract Background Cranial nerve involvement is not commonly encountered in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP); this is especially true for involvement of the hypoglossal nerve. Neither Beevor's sign nor its inverted form has previously been described in CIDP. Case presentation A 28-year-old man presented with distal-predominant limb weakness and numbness at the age of 18. A diagnosis of CIDP was made, which was confirmed by electrodiagnostic evidence of demyelination. He responded well to intravenous immunoglobulin and glucocorticoid treatment and achieved remission for 5 years. However, the same symptoms relapsed at the age of 28 and lasted for 10 months. On examination, in addition to limb sensory impairment and muscle weakness, mild bilateral facial paresis, tongue atrophy and fasciculations, and inverted Beevor's sign were also observed. A brief literature review of cranial nerve involvements in CIDP and Beevor's sign or its inverted form were also performed. Conclusions Cranial nerves may be affected in patients with CIDP. Facial palsy is most frequently present, while hypoglossal nerve involvement is rare. Inverted Beevor's sign can appear in CIDP patients.https://doi.org/10.1186/s12883-021-02287-5Chronic inflammatory demyelinating polyneuropathyHypoglossal neuropathyFacial neuropathyBeevor’s sign |
| spellingShingle | Huajian Zhao Yiming Zheng Lingchao Meng Meng Yu Wei Zhang He Lv Zhaoxia Wang Hongjun Hao Yun Yuan Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case report BMC Neurology Chronic inflammatory demyelinating polyneuropathy Hypoglossal neuropathy Facial neuropathy Beevor’s sign |
| title | Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case report |
| title_full | Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case report |
| title_fullStr | Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case report |
| title_full_unstemmed | Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case report |
| title_short | Chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted Beevor’s sign: case report |
| title_sort | chronic inflammatory demyelinating polyneuropathy with hypoglossal nerve involvement and inverted beevor s sign case report |
| topic | Chronic inflammatory demyelinating polyneuropathy Hypoglossal neuropathy Facial neuropathy Beevor’s sign |
| url | https://doi.org/10.1186/s12883-021-02287-5 |
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