New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study
Abstract Background Indications were found that a diagnostic bias could have contributed to the National Cancer Institute’s (NCI) suggestion of a persistent increased mortality risk for nasopharyngeal cancer (NPC). Methods NCI provided the cohort data updated through 2004. We computed local county r...
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| Format: | Article |
| Language: | English |
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BMC
2019-02-01
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| Series: | Journal of Occupational Medicine and Toxicology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12995-019-0224-2 |
| _version_ | 1798042069827059712 |
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| author | Matthias Möhner Yimeng Liu Gary M. Marsh |
| author_facet | Matthias Möhner Yimeng Liu Gary M. Marsh |
| author_sort | Matthias Möhner |
| collection | DOAJ |
| description | Abstract Background Indications were found that a diagnostic bias could have contributed to the National Cancer Institute’s (NCI) suggestion of a persistent increased mortality risk for nasopharyngeal cancer (NPC). Methods NCI provided the cohort data updated through 2004. We computed local county rate-based standardized mortality ratios (SMRs) for NPC and all other entities of the pharynx for two time periods. Moreover, SMRs were calculated for pharyngeal cancer in relation to study site by cumulative exposure to formaldehyde (FA). Results Overall, our results corroborate the indications of a diagnostic bias by strong but contrary temporal trends for NPC and pharynx, not specified. Moreover, it was shown that mortality risks were increased in the Wallingford cohort for all pharyngeal cancer combined and for pharyngeal cancer excluding NPC. In contrast, no increased risks for these categories were found in the nine other study sites combined. Conclusions Our re-analysis provided little or no evidence to support NCI’s suggestion of a persistent association between FA exposure and mortality from NPC. |
| first_indexed | 2024-04-11T22:30:22Z |
| format | Article |
| id | doaj.art-879d05165c264b40aa8a02072c0eb1a7 |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-11T22:30:22Z |
| publishDate | 2019-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-879d05165c264b40aa8a02072c0eb1a72022-12-22T03:59:26ZengBMCJournal of Occupational Medicine and Toxicology1745-66732019-02-011411410.1186/s12995-019-0224-2New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort studyMatthias Möhner0Yimeng Liu1Gary M. Marsh2Federal Institute for Occupational Safety and HealthCenter for Occupational Biostatistics and Epidemiology and Department of Biostatistics, 7120 Graduate School of Public Health, University of PittsburghCenter for Occupational Biostatistics and Epidemiology and Department of Biostatistics, 7120 Graduate School of Public Health, University of PittsburghAbstract Background Indications were found that a diagnostic bias could have contributed to the National Cancer Institute’s (NCI) suggestion of a persistent increased mortality risk for nasopharyngeal cancer (NPC). Methods NCI provided the cohort data updated through 2004. We computed local county rate-based standardized mortality ratios (SMRs) for NPC and all other entities of the pharynx for two time periods. Moreover, SMRs were calculated for pharyngeal cancer in relation to study site by cumulative exposure to formaldehyde (FA). Results Overall, our results corroborate the indications of a diagnostic bias by strong but contrary temporal trends for NPC and pharynx, not specified. Moreover, it was shown that mortality risks were increased in the Wallingford cohort for all pharyngeal cancer combined and for pharyngeal cancer excluding NPC. In contrast, no increased risks for these categories were found in the nine other study sites combined. Conclusions Our re-analysis provided little or no evidence to support NCI’s suggestion of a persistent association between FA exposure and mortality from NPC.http://link.springer.com/article/10.1186/s12995-019-0224-2FormaldehydeNasopharyngeal cancerCohort mortality studyOccupational healthNational Cancer InstituteRe-analyses |
| spellingShingle | Matthias Möhner Yimeng Liu Gary M. Marsh New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study Journal of Occupational Medicine and Toxicology Formaldehyde Nasopharyngeal cancer Cohort mortality study Occupational health National Cancer Institute Re-analyses |
| title | New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study |
| title_full | New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study |
| title_fullStr | New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study |
| title_full_unstemmed | New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study |
| title_short | New insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study |
| title_sort | new insights into the mortality risk from nasopharyngeal cancer in the national cancer institute formaldehyde worker cohort study |
| topic | Formaldehyde Nasopharyngeal cancer Cohort mortality study Occupational health National Cancer Institute Re-analyses |
| url | http://link.springer.com/article/10.1186/s12995-019-0224-2 |
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