Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy
IntroductionGanglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognostic...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.946201/full |
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| author | Yue Hu Huawei Zhang Aihemaitiniyazi Adilijiang Jian Zhou Jian Zhou Yuguang Guan Yuguang Guan Xueling Qi Mengyang Wang Jing Wang Xiongfei Wang Changqing Liu Changqing Liu Guoming Luan Guoming Luan |
| author_facet | Yue Hu Huawei Zhang Aihemaitiniyazi Adilijiang Jian Zhou Jian Zhou Yuguang Guan Yuguang Guan Xueling Qi Mengyang Wang Jing Wang Xiongfei Wang Changqing Liu Changqing Liu Guoming Luan Guoming Luan |
| author_sort | Yue Hu |
| collection | DOAJ |
| description | IntroductionGanglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognostic factors.MethodsThis retrospective study involved clinical data collected from medical records of patients diagnosed with GG pathologically and underwent surgical resection in Sanbo Brain Hospital, Capital Medical University. The seizure outcomes were evaluated based on the International League Against Epilepsy (ILAE) seizure outcome classification. The prognostic factors were identified according to univariate and multivariate analysis.ResultsA total of 222 patients were included, with a mean age at surgery of 19.19 ± 10.93 years. All patients were followed up at least for one year with a mean follow-up duration of 6.28 ± 3.17 years. At the final follow-up, 174 (78.4%) patients achieved ILAE Class 1 or 2. Univariate and multivariate analyses revealed that the short duration of seizures and gross total resection were significant positive factors for seizure-free. Bilateral interictal or ictal epileptiform discharges in preoperative video-electroencephalogram (VEEG) were related to poor seizure outcomes.ConclusionSurgical resection is an effective treatment for patients with epilepsy associated with GGs. The analysis of predictive factors could effectively guide clinical practice and evaluate the prognosis of epilepsy with GG. |
| first_indexed | 2024-04-12T06:44:53Z |
| format | Article |
| id | doaj.art-879d5ce2129f4dcebec364444b4cb848 |
| institution | Directory Open Access Journal |
| issn | 2296-875X |
| language | English |
| last_indexed | 2024-04-12T06:44:53Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Surgery |
| spelling | doaj.art-879d5ce2129f4dcebec364444b4cb8482022-12-22T03:43:37ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-08-01910.3389/fsurg.2022.946201946201Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsyYue Hu0Huawei Zhang1Aihemaitiniyazi Adilijiang2Jian Zhou3Jian Zhou4Yuguang Guan5Yuguang Guan6Xueling Qi7Mengyang Wang8Jing Wang9Xiongfei Wang10Changqing Liu11Changqing Liu12Guoming Luan13Guoming Luan14Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Brain Disorders, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Brain Disorders, Capital Medical University, Beijing, ChinaDepartment of Pathology, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurology, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Brain Disorders, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, ChinaBeijing Institute for Brain Disorders, Capital Medical University, Beijing, ChinaIntroductionGanglioglioma (GG) patients often present with seizures. Although most patients can be seizure-free after tumor resection, some still experience seizures. The present study aimed to analyze a group of GGs patients associated with epilepsy and evaluate the seizure outcomes and prognostic factors.MethodsThis retrospective study involved clinical data collected from medical records of patients diagnosed with GG pathologically and underwent surgical resection in Sanbo Brain Hospital, Capital Medical University. The seizure outcomes were evaluated based on the International League Against Epilepsy (ILAE) seizure outcome classification. The prognostic factors were identified according to univariate and multivariate analysis.ResultsA total of 222 patients were included, with a mean age at surgery of 19.19 ± 10.93 years. All patients were followed up at least for one year with a mean follow-up duration of 6.28 ± 3.17 years. At the final follow-up, 174 (78.4%) patients achieved ILAE Class 1 or 2. Univariate and multivariate analyses revealed that the short duration of seizures and gross total resection were significant positive factors for seizure-free. Bilateral interictal or ictal epileptiform discharges in preoperative video-electroencephalogram (VEEG) were related to poor seizure outcomes.ConclusionSurgical resection is an effective treatment for patients with epilepsy associated with GGs. The analysis of predictive factors could effectively guide clinical practice and evaluate the prognosis of epilepsy with GG.https://www.frontiersin.org/articles/10.3389/fsurg.2022.946201/fullgangliogliomaepilepsysurgical resectionseizure outcomeprognostic factor |
| spellingShingle | Yue Hu Huawei Zhang Aihemaitiniyazi Adilijiang Jian Zhou Jian Zhou Yuguang Guan Yuguang Guan Xueling Qi Mengyang Wang Jing Wang Xiongfei Wang Changqing Liu Changqing Liu Guoming Luan Guoming Luan Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy Frontiers in Surgery ganglioglioma epilepsy surgical resection seizure outcome prognostic factor |
| title | Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy |
| title_full | Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy |
| title_fullStr | Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy |
| title_full_unstemmed | Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy |
| title_short | Seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy |
| title_sort | seizure outcomes and prognostic factors in patients with gangliogliomas associated with epilepsy |
| topic | ganglioglioma epilepsy surgical resection seizure outcome prognostic factor |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.946201/full |
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