Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development
Xingyue He,1 Tianjiao Hao,1 Hongxu Geng,2 Shengzhou Li,1 Chuanjiang Ran,1 Meirong Huo,1 Yan Shen1 1State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 2School of Pharmacy, Yantai University, Yantai, 264005, People’s Republic of Chin...
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Dove Medical Press
2023-12-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/sensitization-strategies-of-lateral-flow-immunochromatography-for-gold-peer-reviewed-fulltext-article-IJN |
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| author | He X Hao T Geng H Li S Ran C Huo M Shen Y |
| author_facet | He X Hao T Geng H Li S Ran C Huo M Shen Y |
| author_sort | He X |
| collection | DOAJ |
| description | Xingyue He,1 Tianjiao Hao,1 Hongxu Geng,2 Shengzhou Li,1 Chuanjiang Ran,1 Meirong Huo,1 Yan Shen1 1State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 2School of Pharmacy, Yantai University, Yantai, 264005, People’s Republic of ChinaCorrespondence: Yan Shen; Meirong Huo, Email shenyan@cpu.edu.cn; meironghuo@cpu.edu.cnAbstract: Gold nanomaterials have become very attractive nanomaterials for biomedical research due to their unique physical and chemical properties, including size dependent optical, magnetic and catalytic properties, surface plasmon resonance (SPR), biological affinity and structural suitability. The performance of biosensing and biodiagnosis can be significantly improved in sensitivity, specificity, speed, contrast, resolution and so on by utilizing multiple optical properties of different gold nanostructures. Lateral flow immunochromatographic assay (LFIA) based on gold nanoparticles (GNPs) has the advantages of simple, fast operation, stable technology, and low cost, making it one of the most widely used in vitro diagnostics (IVDs). However, the traditional colloidal gold (CG)-based LFIA can only achieve qualitative or semi-quantitative detection, and its low detection sensitivity cannot meet the current detection needs. Due to the strong dependence of the optical properties of gold nanomaterials on their shape and surface properties, gold-based nanomaterial modification has brought new possibilities to the IVDs: people have attempted to change the morphology and size of gold nanomaterials themselves or hybrid with other elements for application in LFIA. In this paper, many well-designed plasmonic gold nanostructures for further improving the sensitivity and signal output stability of LFIA have been summarized. In addition, some opportunities and challenges that gold-based LFIA may encounter at present or in the future are also mentioned in this paper. In summary, this paper will demonstrate some feasible strategies for the manufacture of potential gold-based nanobiosensors of post of care testing (POCT) for faster detection and more accurate disease diagnosis.Keywords: gold nanomaterials, LFIA, sensitivity, POCT |
| first_indexed | 2024-03-08T21:16:23Z |
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| id | doaj.art-879d6e8d7f02481fa4d588cb2e3c47c1 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-08T21:16:23Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-879d6e8d7f02481fa4d588cb2e3c47c12023-12-21T17:27:35ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-12-01Volume 187847786389204Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor DevelopmentHe XHao TGeng HLi SRan CHuo MShen YXingyue He,1 Tianjiao Hao,1 Hongxu Geng,2 Shengzhou Li,1 Chuanjiang Ran,1 Meirong Huo,1 Yan Shen1 1State Key Laboratory of Nature Medicines, China Pharmaceutical University, Nanjing, 210009, People’s Republic of China; 2School of Pharmacy, Yantai University, Yantai, 264005, People’s Republic of ChinaCorrespondence: Yan Shen; Meirong Huo, Email shenyan@cpu.edu.cn; meironghuo@cpu.edu.cnAbstract: Gold nanomaterials have become very attractive nanomaterials for biomedical research due to their unique physical and chemical properties, including size dependent optical, magnetic and catalytic properties, surface plasmon resonance (SPR), biological affinity and structural suitability. The performance of biosensing and biodiagnosis can be significantly improved in sensitivity, specificity, speed, contrast, resolution and so on by utilizing multiple optical properties of different gold nanostructures. Lateral flow immunochromatographic assay (LFIA) based on gold nanoparticles (GNPs) has the advantages of simple, fast operation, stable technology, and low cost, making it one of the most widely used in vitro diagnostics (IVDs). However, the traditional colloidal gold (CG)-based LFIA can only achieve qualitative or semi-quantitative detection, and its low detection sensitivity cannot meet the current detection needs. Due to the strong dependence of the optical properties of gold nanomaterials on their shape and surface properties, gold-based nanomaterial modification has brought new possibilities to the IVDs: people have attempted to change the morphology and size of gold nanomaterials themselves or hybrid with other elements for application in LFIA. In this paper, many well-designed plasmonic gold nanostructures for further improving the sensitivity and signal output stability of LFIA have been summarized. In addition, some opportunities and challenges that gold-based LFIA may encounter at present or in the future are also mentioned in this paper. In summary, this paper will demonstrate some feasible strategies for the manufacture of potential gold-based nanobiosensors of post of care testing (POCT) for faster detection and more accurate disease diagnosis.Keywords: gold nanomaterials, LFIA, sensitivity, POCThttps://www.dovepress.com/sensitization-strategies-of-lateral-flow-immunochromatography-for-gold-peer-reviewed-fulltext-article-IJNgold nanomaterialslfiasensitivitypoct |
| spellingShingle | He X Hao T Geng H Li S Ran C Huo M Shen Y Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development International Journal of Nanomedicine gold nanomaterials lfia sensitivity poct |
| title | Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development |
| title_full | Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development |
| title_fullStr | Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development |
| title_full_unstemmed | Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development |
| title_short | Sensitization Strategies of Lateral Flow Immunochromatography for Gold Modified Nanomaterials in Biosensor Development |
| title_sort | sensitization strategies of lateral flow immunochromatography for gold modified nanomaterials in biosensor development |
| topic | gold nanomaterials lfia sensitivity poct |
| url | https://www.dovepress.com/sensitization-strategies-of-lateral-flow-immunochromatography-for-gold-peer-reviewed-fulltext-article-IJN |
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