Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia: an update

Glutamate-N-methyl-D-aspartate receptor modulation and minocycline for the treatment of patients with schizophrenia: an update

Growing consistent evidence indicates that hypofunction of N-methyl-D-aspartate (NMDA) transmission plays a pivotal role in the neuropathophysiology of schizophrenia. Hence, drugs which modulate NMDA neurotransmission are promising approaches to the treatment of schizophrenia. The aim of this articl...

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Bibliographic Details
Main Authors: C. Chaves, C.R. Marque, C. Trzesniak, J.P. Machado de Sousa, A.W. Zuardi, J.A.S. Crippa, S.M. Dursun, J.E. Hallak
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2009-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Schizophrenia
NMDA agonist
Glycine
Glutamate
Clinical trial
Minocycline
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009001100002

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