Natural Compounds as Metabolic Modulators of the Tumor Microenvironment
The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/12/3494 |
| _version_ | 1797530950559596544 |
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| author | Ana S. Dias Luisa Helguero Catarina R. Almeida Iola F. Duarte |
| author_facet | Ana S. Dias Luisa Helguero Catarina R. Almeida Iola F. Duarte |
| author_sort | Ana S. Dias |
| collection | DOAJ |
| description | The tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to ‘(re)-educate’ TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression. |
| first_indexed | 2024-03-10T10:36:13Z |
| format | Article |
| id | doaj.art-87a091f05eb84abf96c0d4f8ee5c01ab |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T10:36:13Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-87a091f05eb84abf96c0d4f8ee5c01ab2023-11-21T23:17:19ZengMDPI AGMolecules1420-30492021-06-012612349410.3390/molecules26123494Natural Compounds as Metabolic Modulators of the Tumor MicroenvironmentAna S. Dias0Luisa Helguero1Catarina R. Almeida2Iola F. Duarte3Department of Chemistry, CICECO—Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Medical Sciences, iBiMED—Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Medical Sciences, iBiMED—Institute of Biomedicine, University of Aveiro, 3810-193 Aveiro, PortugalDepartment of Chemistry, CICECO—Aveiro Institute of Materials, University of Aveiro, 3810-193 Aveiro, PortugalThe tumor microenvironment (TME) is a heterogenous assemblage of malignant and non-malignant cells, including infiltrating immune cells and other stromal cells, together with extracellular matrix and a variety of soluble factors. This complex and dynamic milieu strongly affects tumor differentiation, progression, immune evasion, and response to therapy, thus being an important therapeutic target. The phenotypic and functional features of the various cell types present in the TME are largely dependent on their ability to adopt different metabolic programs. Hence, modulating the metabolism of the cells in the TME, and their metabolic crosstalk, has emerged as a promising strategy in the context of anticancer therapies. Natural compounds offer an attractive tool in this respect as their multiple biological activities can potentially be harnessed to ‘(re)-educate’ TME cells towards antitumoral roles. The present review discusses how natural compounds shape the metabolism of stromal cells in the TME and how this may impact tumor development and progression.https://www.mdpi.com/1420-3049/26/12/3494tumor microenvironmentstromal cellsmetabolismmetabolic modulationnatural compoundsphytochemicals |
| spellingShingle | Ana S. Dias Luisa Helguero Catarina R. Almeida Iola F. Duarte Natural Compounds as Metabolic Modulators of the Tumor Microenvironment Molecules tumor microenvironment stromal cells metabolism metabolic modulation natural compounds phytochemicals |
| title | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
| title_full | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
| title_fullStr | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
| title_full_unstemmed | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
| title_short | Natural Compounds as Metabolic Modulators of the Tumor Microenvironment |
| title_sort | natural compounds as metabolic modulators of the tumor microenvironment |
| topic | tumor microenvironment stromal cells metabolism metabolic modulation natural compounds phytochemicals |
| url | https://www.mdpi.com/1420-3049/26/12/3494 |
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