Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins.
BACKGROUND:Back pain and type 2 diabetes often co-occur, resulting in greater impact on people's health and complexity in their care. Plausible causal mechanisms for this association have been proposed, yet the nature of the link remains unclear. We therefore explored the direction of the assoc...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5378369?pdf=render |
| _version_ | 1828524281487687680 |
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| author | Amabile Dario Manuela Ferreira Kathryn Refshauge Alison Harmer Juan Sánchez-Romera Francisco Pérez-Riquelme Ligia Cisneros Juan Ordoñana Paulo Ferreira |
| author_facet | Amabile Dario Manuela Ferreira Kathryn Refshauge Alison Harmer Juan Sánchez-Romera Francisco Pérez-Riquelme Ligia Cisneros Juan Ordoñana Paulo Ferreira |
| author_sort | Amabile Dario |
| collection | DOAJ |
| description | BACKGROUND:Back pain and type 2 diabetes often co-occur, resulting in greater impact on people's health and complexity in their care. Plausible causal mechanisms for this association have been proposed, yet the nature of the link remains unclear. We therefore explored the direction of the association between type 2 diabetes and chronic back pain in twins, controlling for genetics and early environmental confounding. METHODS:2,096 and 1,098 twins were included in the cross-sectional and longitudinal analyses, respectively. Any or severe (≥ 9) low back pain (LBP), neck pain (NP), and spinal pain (concurrent LBP and NP) and type 2 diabetes were investigated. Sequential analyses were performed using logistic regression. Firstly, twins were analysed unpaired (adjusted age and gender): total sample analyses. Then, to control for genetic and shared environmental factors, a co-twin case-control analysis was performed including monozygotic and dizygotic twin pairs discordant for back pain (cross-sectional only). RESULTS:In the cross-sectional total sample analyses, type 2 diabetes was associated with chronic spinal pain (OR 1.61; 95%CI 1.12 to 2.31), severe chronic spinal pain (OR 3.33; 95%CI 1.47 to 7.53), chronic NP (OR 1.37; 95%CI 1.01 to 1.85), severe chronic NP (OR 2.28; 95%CI 1.24 to 4.21), and severe chronic LBP (OR 1.63; 95%CI 1.00 to 2.64). After further adjustment for genetic and shared environmental factors, none of the associations remained significant. The longitudinal analyses indicated that the presence of type 2 diabetes did not increase the risk of future back pain, or vice-versa, after two to four years. CONCLUSIONS:Chronic back pain (spinal pain, NP, or LBP) was associated with the prevalence of type 2 diabetes. Associations are stronger for severe cases of pain. Future research should investigate the temporal relationships between these conditions with longer follow up in twins. |
| first_indexed | 2024-12-11T20:44:42Z |
| format | Article |
| id | doaj.art-87a0d31a699f48ac9f90afc07478cade |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T20:44:42Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-87a0d31a699f48ac9f90afc07478cade2022-12-22T00:51:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01124e017475710.1371/journal.pone.0174757Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins.Amabile DarioManuela FerreiraKathryn RefshaugeAlison HarmerJuan Sánchez-RomeraFrancisco Pérez-RiquelmeLigia CisnerosJuan OrdoñanaPaulo FerreiraBACKGROUND:Back pain and type 2 diabetes often co-occur, resulting in greater impact on people's health and complexity in their care. Plausible causal mechanisms for this association have been proposed, yet the nature of the link remains unclear. We therefore explored the direction of the association between type 2 diabetes and chronic back pain in twins, controlling for genetics and early environmental confounding. METHODS:2,096 and 1,098 twins were included in the cross-sectional and longitudinal analyses, respectively. Any or severe (≥ 9) low back pain (LBP), neck pain (NP), and spinal pain (concurrent LBP and NP) and type 2 diabetes were investigated. Sequential analyses were performed using logistic regression. Firstly, twins were analysed unpaired (adjusted age and gender): total sample analyses. Then, to control for genetic and shared environmental factors, a co-twin case-control analysis was performed including monozygotic and dizygotic twin pairs discordant for back pain (cross-sectional only). RESULTS:In the cross-sectional total sample analyses, type 2 diabetes was associated with chronic spinal pain (OR 1.61; 95%CI 1.12 to 2.31), severe chronic spinal pain (OR 3.33; 95%CI 1.47 to 7.53), chronic NP (OR 1.37; 95%CI 1.01 to 1.85), severe chronic NP (OR 2.28; 95%CI 1.24 to 4.21), and severe chronic LBP (OR 1.63; 95%CI 1.00 to 2.64). After further adjustment for genetic and shared environmental factors, none of the associations remained significant. The longitudinal analyses indicated that the presence of type 2 diabetes did not increase the risk of future back pain, or vice-versa, after two to four years. CONCLUSIONS:Chronic back pain (spinal pain, NP, or LBP) was associated with the prevalence of type 2 diabetes. Associations are stronger for severe cases of pain. Future research should investigate the temporal relationships between these conditions with longer follow up in twins.http://europepmc.org/articles/PMC5378369?pdf=render |
| spellingShingle | Amabile Dario Manuela Ferreira Kathryn Refshauge Alison Harmer Juan Sánchez-Romera Francisco Pérez-Riquelme Ligia Cisneros Juan Ordoñana Paulo Ferreira Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins. PLoS ONE |
| title | Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins. |
| title_full | Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins. |
| title_fullStr | Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins. |
| title_full_unstemmed | Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins. |
| title_short | Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins. |
| title_sort | mapping the association between back pain and type 2 diabetes a cross sectional and longitudinal study of adult spanish twins |
| url | http://europepmc.org/articles/PMC5378369?pdf=render |
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