Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity
Inborn Errors of Immunity (IEI) comprise more than 450 inherited diseases, from which selected patients manifest a frequent and early incidence of malignancies, mainly lymphoma and leukemia. Primary antibody deficiency (PAD) is the most common form of IEI with the highest proportion of malignant cas...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2021.720025/full |
| _version_ | 1819137656294998016 |
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| author | Hassan Abolhassani Hassan Abolhassani Hassan Abolhassani Yating Wang Lennart Hammarström Lennart Hammarström Qiang Pan-Hammarström |
| author_facet | Hassan Abolhassani Hassan Abolhassani Hassan Abolhassani Yating Wang Lennart Hammarström Lennart Hammarström Qiang Pan-Hammarström |
| author_sort | Hassan Abolhassani |
| collection | DOAJ |
| description | Inborn Errors of Immunity (IEI) comprise more than 450 inherited diseases, from which selected patients manifest a frequent and early incidence of malignancies, mainly lymphoma and leukemia. Primary antibody deficiency (PAD) is the most common form of IEI with the highest proportion of malignant cases. In this review, we aimed to compare the oncologic hallmarks and the molecular defects underlying PAD with other IEI entities to dissect the impact of avoiding immune destruction, genome instability, and mutation, enabling replicative immortality, tumor-promoting inflammation, resisting cell death, sustaining proliferative signaling, evading growth suppressors, deregulating cellular energetics, inducing angiogenesis, and activating invasion and metastasis in these groups of patients. Moreover, some of the most promising approaches that could be clinically tested in both PAD and IEI patients were discussed. |
| first_indexed | 2024-12-22T10:54:20Z |
| format | Article |
| id | doaj.art-87a13461417047008882c6f17eed11e8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T10:54:20Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-87a13461417047008882c6f17eed11e82022-12-21T18:28:40ZengFrontiers Media S.A.Frontiers in Immunology1664-32242021-08-011210.3389/fimmu.2021.720025720025Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of ImmunityHassan Abolhassani0Hassan Abolhassani1Hassan Abolhassani2Yating Wang3Lennart Hammarström4Lennart Hammarström5Qiang Pan-Hammarström6Division of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, SwedenDivision of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Science, Tehran, IranDivision of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, SwedenDivision of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, SwedenDivision of Clinical Immunology, Department of Laboratory Medicine, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, SwedenDivision of Clinical Immunology, Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, SwedenInborn Errors of Immunity (IEI) comprise more than 450 inherited diseases, from which selected patients manifest a frequent and early incidence of malignancies, mainly lymphoma and leukemia. Primary antibody deficiency (PAD) is the most common form of IEI with the highest proportion of malignant cases. In this review, we aimed to compare the oncologic hallmarks and the molecular defects underlying PAD with other IEI entities to dissect the impact of avoiding immune destruction, genome instability, and mutation, enabling replicative immortality, tumor-promoting inflammation, resisting cell death, sustaining proliferative signaling, evading growth suppressors, deregulating cellular energetics, inducing angiogenesis, and activating invasion and metastasis in these groups of patients. Moreover, some of the most promising approaches that could be clinically tested in both PAD and IEI patients were discussed.https://www.frontiersin.org/articles/10.3389/fimmu.2021.720025/fullinborn errors of immunityprimary immunodeficiencypredominantly antibody deficiencyhallmarks of cancerimmune dysregulationgenome instability |
| spellingShingle | Hassan Abolhassani Hassan Abolhassani Hassan Abolhassani Yating Wang Lennart Hammarström Lennart Hammarström Qiang Pan-Hammarström Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity Frontiers in Immunology inborn errors of immunity primary immunodeficiency predominantly antibody deficiency hallmarks of cancer immune dysregulation genome instability |
| title | Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity |
| title_full | Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity |
| title_fullStr | Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity |
| title_full_unstemmed | Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity |
| title_short | Hallmarks of Cancers: Primary Antibody Deficiency Versus Other Inborn Errors of Immunity |
| title_sort | hallmarks of cancers primary antibody deficiency versus other inborn errors of immunity |
| topic | inborn errors of immunity primary immunodeficiency predominantly antibody deficiency hallmarks of cancer immune dysregulation genome instability |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2021.720025/full |
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