Proton MR Spectroscopy in leukodystrophies
Objective: To analyze MR Spectroscopic findings and metabolite ratios in regions of abnormal signal in children with leukodystrophies. Methods: This prospective study was carried out on twenty-six children (17 males and 9 females); median age, 36 months ± 54 inter-quartile range. The imaging protoco...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2015-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X15001941 |
| _version_ | 1819034611541344256 |
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| author | Eman Muhammad Abdelsalam Germeen Albeir Ashamallah Mahmoud Abdel Lateef Khaled Fathy |
| author_facet | Eman Muhammad Abdelsalam Germeen Albeir Ashamallah Mahmoud Abdel Lateef Khaled Fathy |
| author_sort | Eman Muhammad Abdelsalam |
| collection | DOAJ |
| description | Objective: To analyze MR Spectroscopic findings and metabolite ratios in regions of abnormal signal in children with leukodystrophies.
Methods: This prospective study was carried out on twenty-six children (17 males and 9 females); median age, 36 months ± 54 inter-quartile range. The imaging protocol included axial T1 and T2-weighted spin-echo and FLAIR images, and coronal and sagittal T2-weighted spin-echo images. 1H-MRSI was performed during the same session for all patients. Spectra were acquired from a volume of interest in the affected white matter and intravoxel (NAA/Cr, Cho/Cr, and Cho/NAA) ratios were calculated.
Results: Spectroscopic analysis revealed abnormal (NAA/Cr, Cho/Cr, and Cho/NAA) ratios. Some were highly characteristic and specific as markedly elevated NAA resonance peak in cases with Canavan’s disease and significantly elevated lactate resonance peak in Leigh disease and MELAS syndrome. In the majority of cases, elevated Cho/Cr, decreased NAA/Cr and elevated Cho/NAA ratios were the dominant finding. One-way analysis of variance for the spectroscopic metabolite ratios revealed statistical significance (p < 0.0001).
Conclusion: Proton MR Spectroscopy complementary to conventional MRI proved to be a valuable tool to establish the diagnosis of leukodystrophies. |
| first_indexed | 2024-12-21T07:36:29Z |
| format | Article |
| id | doaj.art-87a28f3e7e6f44889e0ca5059cc662c5 |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-21T07:36:29Z |
| publishDate | 2015-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-87a28f3e7e6f44889e0ca5059cc662c52022-12-21T19:11:26ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2015-12-014641091109710.1016/j.ejrnm.2015.08.013Proton MR Spectroscopy in leukodystrophiesEman Muhammad Abdelsalam0Germeen Albeir Ashamallah1Mahmoud Abdel Lateef2Khaled Fathy3Diagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, EgyptDiagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, EgyptDiagnostic Radiology Department, Mansoura Faculty of Medicine, Mansoura University, Mansoura, EgyptPediatrics Department, Faculty of Medicine, Mansoura University Children’s Hospital, EgyptObjective: To analyze MR Spectroscopic findings and metabolite ratios in regions of abnormal signal in children with leukodystrophies. Methods: This prospective study was carried out on twenty-six children (17 males and 9 females); median age, 36 months ± 54 inter-quartile range. The imaging protocol included axial T1 and T2-weighted spin-echo and FLAIR images, and coronal and sagittal T2-weighted spin-echo images. 1H-MRSI was performed during the same session for all patients. Spectra were acquired from a volume of interest in the affected white matter and intravoxel (NAA/Cr, Cho/Cr, and Cho/NAA) ratios were calculated. Results: Spectroscopic analysis revealed abnormal (NAA/Cr, Cho/Cr, and Cho/NAA) ratios. Some were highly characteristic and specific as markedly elevated NAA resonance peak in cases with Canavan’s disease and significantly elevated lactate resonance peak in Leigh disease and MELAS syndrome. In the majority of cases, elevated Cho/Cr, decreased NAA/Cr and elevated Cho/NAA ratios were the dominant finding. One-way analysis of variance for the spectroscopic metabolite ratios revealed statistical significance (p < 0.0001). Conclusion: Proton MR Spectroscopy complementary to conventional MRI proved to be a valuable tool to establish the diagnosis of leukodystrophies.http://www.sciencedirect.com/science/article/pii/S0378603X15001941SpectroscopyLeukodystrophiesMRI |
| spellingShingle | Eman Muhammad Abdelsalam Germeen Albeir Ashamallah Mahmoud Abdel Lateef Khaled Fathy Proton MR Spectroscopy in leukodystrophies The Egyptian Journal of Radiology and Nuclear Medicine Spectroscopy Leukodystrophies MRI |
| title | Proton MR Spectroscopy in leukodystrophies |
| title_full | Proton MR Spectroscopy in leukodystrophies |
| title_fullStr | Proton MR Spectroscopy in leukodystrophies |
| title_full_unstemmed | Proton MR Spectroscopy in leukodystrophies |
| title_short | Proton MR Spectroscopy in leukodystrophies |
| title_sort | proton mr spectroscopy in leukodystrophies |
| topic | Spectroscopy Leukodystrophies MRI |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X15001941 |
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