Schistosoma mansoni: control of female fertility by the male
We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1995-04-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010 |
| _version_ | 1797715795843743744 |
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| author | Werner Kunz Lutz Gohr Christoph Grevelding Peter Schüssler Gabriele Sommer Marion Menrath Anja Michel |
| author_facet | Werner Kunz Lutz Gohr Christoph Grevelding Peter Schüssler Gabriele Sommer Marion Menrath Anja Michel |
| author_sort | Werner Kunz |
| collection | DOAJ |
| description | We have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation. |
| first_indexed | 2024-03-12T08:12:02Z |
| format | Article |
| id | doaj.art-87a2d274cd69490ebf7c69e6b650cb5b |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:12:02Z |
| publishDate | 1995-04-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-87a2d274cd69490ebf7c69e6b650cb5b2023-09-02T19:06:39ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601995-04-0190218518910.1590/S0074-02761995000200010Schistosoma mansoni: control of female fertility by the maleWerner KunzLutz GohrChristoph GreveldingPeter SchüsslerGabriele SommerMarion MenrathAnja MichelWe have established an in vitro culture system for adult schistosomes that allows monitoring gene expression for up to more than ten days. Comparing female worms that are paired with those that have been separated, we find distinct differences, clearly documenting an influence of the male in female gene expression. In perfect coincidence with classical observations that were based on histological techniques, we find that the male particularly regulates gene expression in those tissues that are characterized by cell proliferation, e.g. the vitellaria. From these results, we hypothesize that the key target for the inductive signal that is transferred from the male to the female during pairing is the activation of a growth factor that stimulates mitotic proliferation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010Schistosoma mansoniin vitro culturegene expressionmalefemale interaction |
| spellingShingle | Werner Kunz Lutz Gohr Christoph Grevelding Peter Schüssler Gabriele Sommer Marion Menrath Anja Michel Schistosoma mansoni: control of female fertility by the male Memorias do Instituto Oswaldo Cruz Schistosoma mansoni in vitro culture gene expression male female interaction |
| title | Schistosoma mansoni: control of female fertility by the male |
| title_full | Schistosoma mansoni: control of female fertility by the male |
| title_fullStr | Schistosoma mansoni: control of female fertility by the male |
| title_full_unstemmed | Schistosoma mansoni: control of female fertility by the male |
| title_short | Schistosoma mansoni: control of female fertility by the male |
| title_sort | schistosoma mansoni control of female fertility by the male |
| topic | Schistosoma mansoni in vitro culture gene expression male female interaction |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761995000200010 |
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