Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing a progressive motor weakness of all voluntary muscles, whose progression challenges communication modalities such as handwriting or speech. The current study investigated whether ALS subjects can use Eye-On-Line (EOL), a nov...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnins.2019.00538/full |
| _version_ | 1818647970742009856 |
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| author | Timothée Lenglet Timothée Lenglet Jonathan Mirault Marie Veyrat-Masson Aurélie Funkiewiez Aurélie Funkiewiez Maria del Mar Amador Gaelle Bruneteau Gaelle Bruneteau Nadine Le Forestier Nadine Le Forestier Pierre-Francois Pradat Pierre-Francois Pradat Pierre-Francois Pradat Francois Salachas Yannick Vacher Lucette Lacomblez Jean Lorenceau Jean Lorenceau |
| author_facet | Timothée Lenglet Timothée Lenglet Jonathan Mirault Marie Veyrat-Masson Aurélie Funkiewiez Aurélie Funkiewiez Maria del Mar Amador Gaelle Bruneteau Gaelle Bruneteau Nadine Le Forestier Nadine Le Forestier Pierre-Francois Pradat Pierre-Francois Pradat Pierre-Francois Pradat Francois Salachas Yannick Vacher Lucette Lacomblez Jean Lorenceau Jean Lorenceau |
| author_sort | Timothée Lenglet |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing a progressive motor weakness of all voluntary muscles, whose progression challenges communication modalities such as handwriting or speech. The current study investigated whether ALS subjects can use Eye-On-Line (EOL), a novel eye-operated communication device allowing, after training, to voluntarily control smooth-pursuit eye-movements (SPEM) so as to eye-write in cursive. To that aim, ALS participants (n = 12) with preserved eye-movements but impaired handwriting were trained during six on-site visits. The primary outcome of the study was the recognition of eye-written digits (0–9) from ALS and healthy control subjects by naïve “readers.” Changes in oculomotor performance and the safety of EOL were also evaluated. At the end of the program, 69.4% of the eye-written digits from 11 ALS subjects were recognized by naïve readers, similar to the 67.3% found for eye-written digits from controls participants, with however, large inter-individual differences in both groups of “writers.” Training with EOL was associated with a transient fatigue leading one ALS subject to drop out the study at the fifth visit. Otherwise, itching eyes was the most common adverse event (3 subjects). This study shows that, despite the impact of ALS on the motor system, most ALS participants could improve their mastering of eye-movements, so as to produce recognizable eye-written digits, although the eye-traces sometimes needed smoothing to ease digit legibility from both ALS subjects and control participants. The capability to endogenously and voluntarily generate eye-traces using EOL brings a novel way to communicate for disabled individuals, allowing creative personal and emotional expression. |
| first_indexed | 2024-12-17T01:11:00Z |
| format | Article |
| id | doaj.art-87a44b4522da4f96abdbf415831a2581 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-17T01:11:00Z |
| publishDate | 2019-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-87a44b4522da4f96abdbf415831a25812022-12-21T22:09:09ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2019-05-011310.3389/fnins.2019.00538440105Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral SclerosisTimothée Lenglet0Timothée Lenglet1Jonathan Mirault2Marie Veyrat-Masson3Aurélie Funkiewiez4Aurélie Funkiewiez5Maria del Mar Amador6Gaelle Bruneteau7Gaelle Bruneteau8Nadine Le Forestier9Nadine Le Forestier10Pierre-Francois Pradat11Pierre-Francois Pradat12Pierre-Francois Pradat13Francois Salachas14Yannick Vacher15Lucette Lacomblez16Jean Lorenceau17Jean Lorenceau18Département de Neurologie, Centre de Référence SLA-IdF, Hôpital Pitié Salpêtrière, AP-HP, Paris, FranceDépartement de Neurophysiologie, Hôpital Pitié Salpêtrière, AP-HP, Paris, FranceLaboratoire des Systèmes Perceptifs (UMR 8248), Département d’Études Cognitives de l’École Normale Supérieure, Paris, FranceLaboratoire des Systèmes Perceptifs (UMR 8248), Département d’Études Cognitives de l’École Normale Supérieure, Paris, FranceInstitut du Cerveau et de la Moelle Epinière (ICM), UMRS 975, ICM-INSERM 1127, FrontLab, Paris, FranceDépartement de Neurologie, Institut de la Mémoire et de la Maladie d’Alzheimer, Centre de Référence National ‘Démences Rares’, Hôpital Pitié Salpêtrière, AP-HP, Paris, FranceDépartement de Neurologie, Centre de Référence SLA-IdF, Hôpital Pitié Salpêtrière, AP-HP, Paris, FranceDépartement de Neurologie, Centre de Référence SLA-IdF, Hôpital Pitié Salpêtrière, AP-HP, Paris, FranceCentre de Recherche en Myologie, UMRS974, Equipe 10 NMCONNECT, Sorbonne Université, Paris, FranceDépartement de Neurologie, Centre de Référence SLA-IdF, Hôpital Pitié Salpêtrière, AP-HP, Paris, FranceDépartement de Recherche en Éthique, EA 1610: Etude des Sciences et Techniques, Université Paris Sud/Paris Saclay, Paris, FranceDépartement de Neurologie, Centre de Référence SLA-IdF, Hôpital Pitié Salpêtrière, AP-HP, Paris, FranceSorbonne Université, CNRS, INSERM, Laboratoire d’Imagerie Biomédicale, Paris, FranceNorthern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute Ulster University, C-TRIC, Altnagelvin Area Hospital, Londonderry, United KingdomDépartement de Neurologie, Centre de Référence SLA-IdF, Hôpital Pitié Salpêtrière, AP-HP, Paris, France0Délégation à la Recherche Clinique et à l’Innovation (DRCI), Hôpital Saint-Louis, APHP, Paris, France1Sorbonne Université, INSERM UMRS 1127 and CIC-1422, ICM, Hôpital Pitié Salpêtrière, Département de Neurologie, AP-HP, Paris, FranceLaboratoire des Systèmes Perceptifs (UMR 8248), Département d’Études Cognitives de l’École Normale Supérieure, Paris, France2Sorbonne Université, Institut de la Vision, Inserm UMR S 968-CNRS UMR 7210, Paris, FranceAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing a progressive motor weakness of all voluntary muscles, whose progression challenges communication modalities such as handwriting or speech. The current study investigated whether ALS subjects can use Eye-On-Line (EOL), a novel eye-operated communication device allowing, after training, to voluntarily control smooth-pursuit eye-movements (SPEM) so as to eye-write in cursive. To that aim, ALS participants (n = 12) with preserved eye-movements but impaired handwriting were trained during six on-site visits. The primary outcome of the study was the recognition of eye-written digits (0–9) from ALS and healthy control subjects by naïve “readers.” Changes in oculomotor performance and the safety of EOL were also evaluated. At the end of the program, 69.4% of the eye-written digits from 11 ALS subjects were recognized by naïve readers, similar to the 67.3% found for eye-written digits from controls participants, with however, large inter-individual differences in both groups of “writers.” Training with EOL was associated with a transient fatigue leading one ALS subject to drop out the study at the fifth visit. Otherwise, itching eyes was the most common adverse event (3 subjects). This study shows that, despite the impact of ALS on the motor system, most ALS participants could improve their mastering of eye-movements, so as to produce recognizable eye-written digits, although the eye-traces sometimes needed smoothing to ease digit legibility from both ALS subjects and control participants. The capability to endogenously and voluntarily generate eye-traces using EOL brings a novel way to communicate for disabled individuals, allowing creative personal and emotional expression.https://www.frontiersin.org/article/10.3389/fnins.2019.00538/fullamyotrophic lateral sclerosisassisted communication devicessmooth-pursuit eye movementspilot clinical studymotor learning |
| spellingShingle | Timothée Lenglet Timothée Lenglet Jonathan Mirault Marie Veyrat-Masson Aurélie Funkiewiez Aurélie Funkiewiez Maria del Mar Amador Gaelle Bruneteau Gaelle Bruneteau Nadine Le Forestier Nadine Le Forestier Pierre-Francois Pradat Pierre-Francois Pradat Pierre-Francois Pradat Francois Salachas Yannick Vacher Lucette Lacomblez Jean Lorenceau Jean Lorenceau Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis Frontiers in Neuroscience amyotrophic lateral sclerosis assisted communication devices smooth-pursuit eye movements pilot clinical study motor learning |
| title | Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis |
| title_full | Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis |
| title_fullStr | Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis |
| title_short | Cursive Eye-Writing With Smooth-Pursuit Eye-Movement Is Possible in Subjects With Amyotrophic Lateral Sclerosis |
| title_sort | cursive eye writing with smooth pursuit eye movement is possible in subjects with amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis assisted communication devices smooth-pursuit eye movements pilot clinical study motor learning |
| url | https://www.frontiersin.org/article/10.3389/fnins.2019.00538/full |
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