Synergistic assembly of human pre-spliceosomes across introns and exons

Synergistic assembly of human pre-spliceosomes across introns and exons

Most human genes contain multiple introns, necessitating mechanisms to effectively define exons and ensure their proper connection by spliceosomes. Human spliceosome assembly involves both cross-intron and cross-exon interactions, but how these work together is unclear. We examined in human nuclear...

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Bibliographic Details
Main Authors: Joerg E Braun, Larry J Friedman, Jeff Gelles, Melissa J Moore
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-06-01
Series:eLife
Subjects:
splicing
spliceosome
single-molecule
RNA
snRNP
CoSMoS
Online Access:https://elifesciences.org/articles/37751

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