Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series
BackgroundLiterature suggests an association between patent foramen ovale (PFO) and migraine, mostly migraine with aura (MA). Previous data suggest that air microembolism through PFO can lead to bioelectrical abnormalities detectable at electroencephalogram (EEG) in patients with MA, thus suggesting...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.1034714/full |
| _version_ | 1811196451613573120 |
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| author | Raffaele Ornello Matteo Spezialetti Valeria Caponnetto Ilaria Frattale Monica Grappasonni Francesca Pistoia Giuseppe Placidi Simona Sacco |
| author_facet | Raffaele Ornello Matteo Spezialetti Valeria Caponnetto Ilaria Frattale Monica Grappasonni Francesca Pistoia Giuseppe Placidi Simona Sacco |
| author_sort | Raffaele Ornello |
| collection | DOAJ |
| description | BackgroundLiterature suggests an association between patent foramen ovale (PFO) and migraine, mostly migraine with aura (MA). Previous data suggest that air microembolism through PFO can lead to bioelectrical abnormalities detectable at electroencephalogram (EEG) in patients with MA, thus suggesting a pathophysiological mechanism for the MA-PFO association. However, those data lack replication.MethodsPatients with MA or migraine without aura (MO) and large PFO underwent a 19-channel EEG recording before and after injection of air microbubbles. We compared EEG power before and after microbubble injection for each electrode location, for each frequency band (theta: 5–7 Hz; alpha: 8–12 Hz; beta: 13–30 Hz; lower gamma: 31–45 Hz), and for total global power (the average of EEG power at each location and frequency band).ResultsWe included 10 patients, four with MA and six with MO; six patients had medium-to-high migraine frequency (four or more monthly migraine days), while four had low frequency (one monthly migraine day). EEG power changes after air microembolism varied across patients. Considering the overall group, total global EEG power did not change; however, EEG power in the higher frequency ranges (beta and lower gamma) increased in patients with MA.ConclusionsWe did not replicate the effects of air microembolism previously reported in patients with migraine. Aura status, migraine frequency, and medications might influence patients' response to microembolism. More refined EEG measurements are needed to clarify the dynamic role of PFO on migraine occurrence. |
| first_indexed | 2024-04-12T00:59:07Z |
| format | Article |
| id | doaj.art-87a63c27aa214b6fb63c604dc3d31f74 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T00:59:07Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-87a63c27aa214b6fb63c604dc3d31f742022-12-22T03:54:31ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-12-011310.3389/fneur.2022.10347141034714Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case seriesRaffaele Ornello0Matteo Spezialetti1Valeria Caponnetto2Ilaria Frattale3Monica Grappasonni4Francesca Pistoia5Giuseppe Placidi6Simona Sacco7Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, ItalyDepartment of Information Engineering, Computer Science and Mathematics, University of L'Aquila, L'Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, ItalyChild Neurology and Neuropsychiatry Unit, Department of Systems Medicine, Tor Vergata University, Rome, ItalyDepartment of Neurology and Stroke Unit, SS Filippo e Nicola Hospital, Avezzano, L'Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, ItalyA2VI (Acquisition, Analysis, Visualization & Imaging Laboratory) Laboratory, Department of Life, Health and Environmental Sciences (MESVA), University of L'Aquila, L'Aquila, ItalyDepartment of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, ItalyBackgroundLiterature suggests an association between patent foramen ovale (PFO) and migraine, mostly migraine with aura (MA). Previous data suggest that air microembolism through PFO can lead to bioelectrical abnormalities detectable at electroencephalogram (EEG) in patients with MA, thus suggesting a pathophysiological mechanism for the MA-PFO association. However, those data lack replication.MethodsPatients with MA or migraine without aura (MO) and large PFO underwent a 19-channel EEG recording before and after injection of air microbubbles. We compared EEG power before and after microbubble injection for each electrode location, for each frequency band (theta: 5–7 Hz; alpha: 8–12 Hz; beta: 13–30 Hz; lower gamma: 31–45 Hz), and for total global power (the average of EEG power at each location and frequency band).ResultsWe included 10 patients, four with MA and six with MO; six patients had medium-to-high migraine frequency (four or more monthly migraine days), while four had low frequency (one monthly migraine day). EEG power changes after air microembolism varied across patients. Considering the overall group, total global EEG power did not change; however, EEG power in the higher frequency ranges (beta and lower gamma) increased in patients with MA.ConclusionsWe did not replicate the effects of air microembolism previously reported in patients with migraine. Aura status, migraine frequency, and medications might influence patients' response to microembolism. More refined EEG measurements are needed to clarify the dynamic role of PFO on migraine occurrence.https://www.frontiersin.org/articles/10.3389/fneur.2022.1034714/fullmigrainepatent foramen ovalemicroembolismmigraine with auraelectroencephalogram |
| spellingShingle | Raffaele Ornello Matteo Spezialetti Valeria Caponnetto Ilaria Frattale Monica Grappasonni Francesca Pistoia Giuseppe Placidi Simona Sacco Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series Frontiers in Neurology migraine patent foramen ovale microembolism migraine with aura electroencephalogram |
| title | Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series |
| title_full | Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series |
| title_fullStr | Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series |
| title_full_unstemmed | Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series |
| title_short | Different effects of air microembolism through patent foramen ovale in patients with migraine: A quantitative electroencephalogram case series |
| title_sort | different effects of air microembolism through patent foramen ovale in patients with migraine a quantitative electroencephalogram case series |
| topic | migraine patent foramen ovale microembolism migraine with aura electroencephalogram |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.1034714/full |
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