A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS
Objective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes. Study Design: Cross sectional study. Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019. Methodology: Consecutive pati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2021-10-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/4918/3594 |
| _version_ | 1818916320419250176 |
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| author | Shehar Bano Imran Shabnam Dildar Sadia Taj Afshan Khanum Qasim Ahmed |
| author_facet | Shehar Bano Imran Shabnam Dildar Sadia Taj Afshan Khanum Qasim Ahmed |
| author_sort | Shehar Bano Imran |
| collection | DOAJ |
| description | Objective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes.
Study Design: Cross sectional study.
Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019.
Methodology: Consecutive patients aged 18-65 years coming for screening of diabetes mellitus (DM) were included. Blood sample for plasma glucose and glycated hemoglobin (HbA1c), high sensitivity CRP (hs-CRP) were analyzed.
Results: Total 93 subjects were included, out of which 42 (45.2%) were males and 51 (54.8%) were females with the mean age of 48.3 ± 12 years and 42.6 ± 14 years respectively. Median concentration of hs-CRP in males and females was 0.7 (IQR1.2) mg/L and 0.6 (IQR1.4) mg/L (p-value=0.844) respectively. A significant positive correlation was observed between hs-CRP levels, HBA1c with r=0.205 (p=0.05) and fasting plasma glucose (FPG) with r=0.225 (p=0.03). However, no significant relationship was found between hs-CRP and age, BMI, waist circumference and systolic blood pressure (SBP) and diastolic blood pressure (DBP), cholesterol, LDL-cholesterol, triglycerides (TG), HDL-cholesterol.
Conclusion: HbA1c and fasting plasma glucose is significantly associated with hs-CRP. This implies a significant relation between inflammation and glycemic markers. This leads to the conclusion that patients with diabetes and high hs-CRP need further evaluation, follow-up and therapy for inflammation compared to those with low hs-CRP. |
| first_indexed | 2024-12-20T00:16:18Z |
| format | Article |
| id | doaj.art-87a7e8f9da13447b92a5904750a29e8e |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-20T00:16:18Z |
| publishDate | 2021-10-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-87a7e8f9da13447b92a5904750a29e8e2022-12-21T20:00:19ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422021-10-0171516511655A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUSShehar Bano Imran0Shabnam Dildar1Sadia Taj2Afshan Khanum3Qasim Ahmed4Fatima Memorial Hospital, Lahore PakistanNational Institute of Blood Disease and Bone Marrow Transplantation, Karachi PakistanFatima Memorial Hospital, Lahore PakistanFatima Memorial Hospital, Lahore PakistanFatima Memorial Hospital, Lahore PakistanObjective: To determine the relationship between high sensitivity CRP (hs-CRP) and glycemic markers in samples of individuals with diabetes. Study Design: Cross sectional study. Place and Duration of Study: Fatima Memorial Hospital Lahore, from Feb to Aug 2019. Methodology: Consecutive patients aged 18-65 years coming for screening of diabetes mellitus (DM) were included. Blood sample for plasma glucose and glycated hemoglobin (HbA1c), high sensitivity CRP (hs-CRP) were analyzed. Results: Total 93 subjects were included, out of which 42 (45.2%) were males and 51 (54.8%) were females with the mean age of 48.3 ± 12 years and 42.6 ± 14 years respectively. Median concentration of hs-CRP in males and females was 0.7 (IQR1.2) mg/L and 0.6 (IQR1.4) mg/L (p-value=0.844) respectively. A significant positive correlation was observed between hs-CRP levels, HBA1c with r=0.205 (p=0.05) and fasting plasma glucose (FPG) with r=0.225 (p=0.03). However, no significant relationship was found between hs-CRP and age, BMI, waist circumference and systolic blood pressure (SBP) and diastolic blood pressure (DBP), cholesterol, LDL-cholesterol, triglycerides (TG), HDL-cholesterol. Conclusion: HbA1c and fasting plasma glucose is significantly associated with hs-CRP. This implies a significant relation between inflammation and glycemic markers. This leads to the conclusion that patients with diabetes and high hs-CRP need further evaluation, follow-up and therapy for inflammation compared to those with low hs-CRP.https://www.pafmj.org/index.php/PAFMJ/article/view/4918/3594high-sensitivity c-reactive proteindiabetes mellitushba1c |
| spellingShingle | Shehar Bano Imran Shabnam Dildar Sadia Taj Afshan Khanum Qasim Ahmed A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS Pakistan Armed Forces Medical Journal high-sensitivity c-reactive protein diabetes mellitus hba1c |
| title | A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS |
| title_full | A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS |
| title_fullStr | A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS |
| title_full_unstemmed | A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS |
| title_short | A COMPARATIVE STUDY OF HIGH SENSITIVITY C-REACTIVE PROTEIN (HS-CRP) AND GLYCEMIC MARKERS IN TYPE 2 DIABETES MELLITUS |
| title_sort | comparative study of high sensitivity c reactive protein hs crp and glycemic markers in type 2 diabetes mellitus |
| topic | high-sensitivity c-reactive protein diabetes mellitus hba1c |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/4918/3594 |
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