PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients

PARP-1 and p53 Regulate the Increased Susceptibility to Oxidative Death of Lymphocytes from MCI and AD Patients

Mild cognitive impairment (MCI) is a clinically detectable initial stage of cognitive deterioration with a high conversion rate to dementia. There is increasing evidence that some of the cerebral alterations present in Alzheimer type dementia can be found in peripheral tissues. We have previously sh...

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Bibliographic Details
Main Authors: Felipe Salech, Daniela P. Ponce, Carol D. SanMartín, Nicole K. Rogers, Carlos Chacón, Mauricio Henríquez, Maria I. Behrens
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
PARP-1
p53
oxidative cell death
lymphocytes
AD
MCI
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00310/full

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