Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke
Abstract Background The neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to examine the associations of NLR with ICAS and ischemic stroke among a...
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| Format: | Article |
| Language: | English |
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BMC
2021-02-01
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| Series: | BMC Neurology |
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| Online Access: | https://doi.org/10.1186/s12883-021-02073-3 |
| _version_ | 1818919486103748608 |
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| author | Liang-Yu Huang Fu-Rong Sun Jian-Jun Yin Ya-Hui Ma Hong-Qi Li Xiao-Ling Zhong Jin-Tai Yu Jing-Hui Song Lan Tan |
| author_facet | Liang-Yu Huang Fu-Rong Sun Jian-Jun Yin Ya-Hui Ma Hong-Qi Li Xiao-Ling Zhong Jin-Tai Yu Jing-Hui Song Lan Tan |
| author_sort | Liang-Yu Huang |
| collection | DOAJ |
| description | Abstract Background The neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to examine the associations of NLR with ICAS and ischemic stroke among a large and high-risk population. Methods Participants with records of clinical characteristics were prospectively recruited from the Neurology Department and Health & Physical Examination Center of Qingdao Municipal Hospital. Logistic regression analysis was used to examine the associations of NLR with ICAS and ischemic stroke. Moreover, we also conducted parametric mediation analysis to estimate the effect of NLR on the risk of ischemic stroke mediated through ICAS. Results A total of 2989 participants were enrolled in this study. After adjusting for covariates, NLR (OR = 1.125, 95%CI 1.070–1.183) and ICAS (OR = 1.638, 95%CI 1.364–1.967) were significantly associated with ischemic stroke. Compared with the first quartile NLR, the second, third and fourth quartiles NLR were independent risk predictors for ischemic stroke (P for trend < 0.001); the third and fourth quartiles were independent predictors for ICAS (P for trend < 0.001). The mediation analysis showed that ICAS partially mediated the association between NLR and ischemic stroke, accounting for 14.4% of the total effect (P < 0.001). Conclusions NLR was significantly associated with ICAS and ischemic stroke. Besides, ICAS partially mediated the association between NLR and ischemic stroke. |
| first_indexed | 2024-12-20T01:06:37Z |
| format | Article |
| id | doaj.art-87a9a62ec2c64569977b4e0d83888bd0 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-20T01:06:37Z |
| publishDate | 2021-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-87a9a62ec2c64569977b4e0d83888bd02022-12-21T19:58:50ZengBMCBMC Neurology1471-23772021-02-012111810.1186/s12883-021-02073-3Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic strokeLiang-Yu Huang0Fu-Rong Sun1Jian-Jun Yin2Ya-Hui Ma3Hong-Qi Li4Xiao-Ling Zhong5Jin-Tai Yu6Jing-Hui Song7Lan Tan8Department of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Hiser Hospital, Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan UniversityDepartment of Neurology, Qingdao Central Hospital, Qingdao UniversityDepartment of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan UniversityDepartment of Neurology, The Affiliated Hospital of Qingdao UniversityDepartment of Neurology, Qingdao Municipal Hospital, Qingdao UniversityAbstract Background The neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker. However, the associations of NLR with intracranial artery stenosis (ICAS) and ischemic stroke remain unclear. This study aimed to examine the associations of NLR with ICAS and ischemic stroke among a large and high-risk population. Methods Participants with records of clinical characteristics were prospectively recruited from the Neurology Department and Health & Physical Examination Center of Qingdao Municipal Hospital. Logistic regression analysis was used to examine the associations of NLR with ICAS and ischemic stroke. Moreover, we also conducted parametric mediation analysis to estimate the effect of NLR on the risk of ischemic stroke mediated through ICAS. Results A total of 2989 participants were enrolled in this study. After adjusting for covariates, NLR (OR = 1.125, 95%CI 1.070–1.183) and ICAS (OR = 1.638, 95%CI 1.364–1.967) were significantly associated with ischemic stroke. Compared with the first quartile NLR, the second, third and fourth quartiles NLR were independent risk predictors for ischemic stroke (P for trend < 0.001); the third and fourth quartiles were independent predictors for ICAS (P for trend < 0.001). The mediation analysis showed that ICAS partially mediated the association between NLR and ischemic stroke, accounting for 14.4% of the total effect (P < 0.001). Conclusions NLR was significantly associated with ICAS and ischemic stroke. Besides, ICAS partially mediated the association between NLR and ischemic stroke.https://doi.org/10.1186/s12883-021-02073-3Intracranial artery stenosisIschemic strokeNeutrophil to lymphocyte ratioMediation analysis |
| spellingShingle | Liang-Yu Huang Fu-Rong Sun Jian-Jun Yin Ya-Hui Ma Hong-Qi Li Xiao-Ling Zhong Jin-Tai Yu Jing-Hui Song Lan Tan Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke BMC Neurology Intracranial artery stenosis Ischemic stroke Neutrophil to lymphocyte ratio Mediation analysis |
| title | Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke |
| title_full | Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke |
| title_fullStr | Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke |
| title_full_unstemmed | Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke |
| title_short | Associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke |
| title_sort | associations of the neutrophil to lymphocyte ratio with intracranial artery stenosis and ischemic stroke |
| topic | Intracranial artery stenosis Ischemic stroke Neutrophil to lymphocyte ratio Mediation analysis |
| url | https://doi.org/10.1186/s12883-021-02073-3 |
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