Ubiquitin-Specific Proteases as Potential Therapeutic Targets in Bladder Cancer—In Vitro Evaluation of Degrasyn and PR-619 Activity Using Human and Canine Models

Ubiquitin-Specific Proteases as Potential Therapeutic Targets in Bladder Cancer—In Vitro Evaluation of Degrasyn and PR-619 Activity Using Human and Canine Models

Background: The inhibition of ubiquitin-specific proteases (USPs) is a novel and promising direction in the development of molecularly targeted therapies in oncology. The aim of the present study was to examine whether Degrasyn could be a potential therapeutic agent against bladder cancer (BC). Also...

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Bibliographic Details
Main Authors: Łukasz Nowak, Wojciech Krajewski, Ewa Dejnaka, Bartosz Małkiewicz, Tomasz Szydełko, Aleksandra Pawlak
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomedicines
Subjects:
bladder cancer
urothelial carcinoma
ubiquitin-specific proteases
Degrasyn
PR-619
Online Access:https://www.mdpi.com/2227-9059/11/3/759

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