Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism
Objective: Glycogen is a major energy reserve in liver and skeletal muscle. The master metabolic regulator AMP-activated protein kinase (AMPK) associates with glycogen via its regulatory β subunit carbohydrate-binding module (CBM). However, the physiological role of AMPK-glycogen binding in energy h...
Main Authors: | Nolan J. Hoffman, Jamie Whitfield, Natalie R. Janzen, Mehdi R. Belhaj, Sandra Galic, Lisa Murray-Segal, William J. Smiles, Naomi X.Y. Ling, Toby A. Dite, John W. Scott, Jonathan S. Oakhill, Robert Brink, Bruce E. Kemp, John A. Hawley |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-11-01
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Series: | Molecular Metabolism |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2212877820301228 |
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