Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial
BackgroundCardiac autonomic function (CAF) decreases with aging, and Acanthopanax senticosus Harms (ASH) consumption reportedly induces anti-stress effects. This study aimed to assess the effect of continuous supplementation of ASH on CAF during resting and standing tests in the elderly population.M...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1336676/full |
| _version_ | 1827323252242907136 |
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| author | Takeru Sato Takumi Aoki Yuki Ito Kan Oishi Masaki Fujishima Eri Okumura Kojiro Ishii |
| author_facet | Takeru Sato Takumi Aoki Yuki Ito Kan Oishi Masaki Fujishima Eri Okumura Kojiro Ishii |
| author_sort | Takeru Sato |
| collection | DOAJ |
| description | BackgroundCardiac autonomic function (CAF) decreases with aging, and Acanthopanax senticosus Harms (ASH) consumption reportedly induces anti-stress effects. This study aimed to assess the effect of continuous supplementation of ASH on CAF during resting and standing tests in the elderly population.MethodsThis double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, Doshisha University (Karasuma-higashi-iru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan). In total, 28 community-dwelling elderly individuals (mean ± standard deviation = 72.5 ± 4.5 years) were included. Each subject was instructed to consume ASH or placebo supplements twice daily for 4 weeks. An autonomic reflex orthostatic tolerance recorder was used to measure CAF in pre- and post-intervention phases. Parameters were measured in a seated position and included coefficient of variation of R-R intervals (CVRR), low frequency (LF), high frequency (HF), LF/HF ratio, blood pressure, and heart rate (HR). Changes in each parameter were evaluated before and after standing. All parameters were defined as the difference between the mean value obtained in a standing position for 2 min and that obtained in a 2-min seated position.ResultsA two-way analysis of variance revealed a significant group-time interaction effect on CVRR, HF, and ΔLF/HF ratio. Following the intervention, CVRR, HF, LF/HF ratio, systolic blood pressure (SBP), HR, ΔLF/HF ratio, ΔSBP, and ΔHR improved significantly in the ASH group only.ConclusionsFour-week supplementation of ASH improved CAF in community-dwelling elderly individuals during resting and standing tests.Clinical Trial Registrationhttps://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000031218, UMIN Clinical Trials Registry (UMIN000027251). |
| first_indexed | 2024-04-25T01:42:14Z |
| format | Article |
| id | doaj.art-87ad080f48cd41678b6fd2d6f9bd94c1 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-25T01:42:14Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-87ad080f48cd41678b6fd2d6f9bd94c12024-03-08T04:37:49ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-03-011110.3389/fcvm.2024.13366761336676Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trialTakeru Sato0Takumi Aoki1Yuki Ito2Kan Oishi3Masaki Fujishima4Eri Okumura5Kojiro Ishii6Graduate School of Health and Sports Science, Doshisha University, Kyo-Tanabe, JapanFaculty of Education, Miyagi Gakuin Women’s University, Sendai, JapanCollege of Life and Health Sciences, Chubu University, Kasugai, JapanGraduate School of Health and Sports Science, Doshisha University, Kyo-Tanabe, JapanSun Chlorella Corp., Kyoto, JapanSun Chlorella Corp., Kyoto, JapanFaculty of Health and Sports Science, Doshisha University, Kyo-Tanabe, JapanBackgroundCardiac autonomic function (CAF) decreases with aging, and Acanthopanax senticosus Harms (ASH) consumption reportedly induces anti-stress effects. This study aimed to assess the effect of continuous supplementation of ASH on CAF during resting and standing tests in the elderly population.MethodsThis double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, Doshisha University (Karasuma-higashi-iru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan). In total, 28 community-dwelling elderly individuals (mean ± standard deviation = 72.5 ± 4.5 years) were included. Each subject was instructed to consume ASH or placebo supplements twice daily for 4 weeks. An autonomic reflex orthostatic tolerance recorder was used to measure CAF in pre- and post-intervention phases. Parameters were measured in a seated position and included coefficient of variation of R-R intervals (CVRR), low frequency (LF), high frequency (HF), LF/HF ratio, blood pressure, and heart rate (HR). Changes in each parameter were evaluated before and after standing. All parameters were defined as the difference between the mean value obtained in a standing position for 2 min and that obtained in a 2-min seated position.ResultsA two-way analysis of variance revealed a significant group-time interaction effect on CVRR, HF, and ΔLF/HF ratio. Following the intervention, CVRR, HF, LF/HF ratio, systolic blood pressure (SBP), HR, ΔLF/HF ratio, ΔSBP, and ΔHR improved significantly in the ASH group only.ConclusionsFour-week supplementation of ASH improved CAF in community-dwelling elderly individuals during resting and standing tests.Clinical Trial Registrationhttps://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000031218, UMIN Clinical Trials Registry (UMIN000027251).https://www.frontiersin.org/articles/10.3389/fcvm.2024.1336676/fullAcanthopanax senticosus Harmscardiac autonomic functionstanding testelderly individualsdizziness |
| spellingShingle | Takeru Sato Takumi Aoki Yuki Ito Kan Oishi Masaki Fujishima Eri Okumura Kojiro Ishii Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial Frontiers in Cardiovascular Medicine Acanthopanax senticosus Harms cardiac autonomic function standing test elderly individuals dizziness |
| title | Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial |
| title_full | Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial |
| title_fullStr | Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial |
| title_full_unstemmed | Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial |
| title_short | Effects of continuous supplementation of Acanthopanax senticosus Harms on the cardiac autonomic function of community-dwelling elderly individuals during resting and standing tests: a randomized controlled trial |
| title_sort | effects of continuous supplementation of acanthopanax senticosus harms on the cardiac autonomic function of community dwelling elderly individuals during resting and standing tests a randomized controlled trial |
| topic | Acanthopanax senticosus Harms cardiac autonomic function standing test elderly individuals dizziness |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1336676/full |
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