Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination

Comparison of mouse models of microbial experience reveals differences in microbial diversity and response to vaccination

ABSTRACTSpecific pathogen-free (SPF) laboratory mice dominate preclinical studies for immunology and vaccinology. Unfortunately, SPF mice often fail to accurately model human responses to vaccination and other immunological perturbations. Several groups have taken different approaches to introduce a...

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Bibliographic Details
Main Authors: Autumn E. Sanders, Henriette Arnesen, Frances K. Shepherd, Dira S. Putri, Jessica K. Fiege, Mark J. Pierson, Shanley N. Roach, Harald Carlsen, David Masopust, Preben Boysen, Ryan A. Langlois
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mSphere
Subjects:
mouse models
vaccines
natural mouse viruses
preclinical models
Online Access:https://journals.asm.org/doi/10.1128/msphere.00654-23

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