Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model
Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on gelation through body heat. It is supposed that the gel can be easily removed by reversing the gelation and washing it away with a cold irri...
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MDPI AG
2023-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/6/5127 |
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| author | Roel C. Op ‘t Veld Lieke Joosten Peter Laverman Ewald M. Bronkhorst John A. Jansen X. Frank Walboomers Frank A. D. T. G. Wagener |
| author_facet | Roel C. Op ‘t Veld Lieke Joosten Peter Laverman Ewald M. Bronkhorst John A. Jansen X. Frank Walboomers Frank A. D. T. G. Wagener |
| author_sort | Roel C. Op ‘t Veld |
| collection | DOAJ |
| description | Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on gelation through body heat. It is supposed that the gel can be easily removed by reversing the gelation and washing it away with a cold irrigation solution. The impact on wound healing of the regular application and removal of PIC dressings is compared to a single application of PIC and the clinically used Tegaderm™ in murine splinted full-thickness wounds for up to 14 days. SPECT/CT analysis of <sup>111</sup>In-labelled PIC gels showed that, on average, 58% of the PIC gel could be washed out of the wounds with the employed method, which is, however, heavily influenced by personal technique. Evaluation with photography and (immuno-)histology showed that wounds in which PIC dressings were regularly removed and replaced were smaller at 14 days post-injury but performed on par with the control treatment. Moreover, the encapsulation of PIC in wound tissue was less severe and occurred less often when PIC was regularly refreshed. In addition, no morphological damage related to the removal procedure was observed. Thus, PIC gels are atraumatic and perform similarly to currently employed wound dressing materials, offering possible future benefits for both clinicians and patients. |
| first_indexed | 2024-03-11T06:27:09Z |
| format | Article |
| id | doaj.art-87af2ed1eff5428b929af89254931ee7 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T06:27:09Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-87af2ed1eff5428b929af89254931ee72023-11-17T11:29:27ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-03-01246512710.3390/ijms24065127Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound ModelRoel C. Op ‘t Veld0Lieke Joosten1Peter Laverman2Ewald M. Bronkhorst3John A. Jansen4X. Frank Walboomers5Frank A. D. T. G. Wagener6Department of Dentistry—Biomaterials, Research Institute for Medical Innovation, Radboud University Medical Centre, 6525 EX Nijmegen, The NetherlandsDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Medical Imaging, Nuclear Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The NetherlandsDepartment of Dentistry, Research Institute for Medical Innovation, Radboud University Medical Centre, 6525 EX Nijmegen, The NetherlandsDepartment of Dentistry—Biomaterials, Research Institute for Medical Innovation, Radboud University Medical Centre, 6525 EX Nijmegen, The NetherlandsDepartment of Dentistry—Biomaterials, Research Institute for Medical Innovation, Radboud University Medical Centre, 6525 EX Nijmegen, The NetherlandsDepartment of Dentistry—Orthodontics and Craniofacial Biology, Research Institute for Medical Innovation, Radboud University Medical Centre, Philips van Leydenlaan 25, 6525 EX Nijmegen, The NetherlandsPolyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings. These gels are thermo-sensitive, allow application as a cold liquid, and rely on gelation through body heat. It is supposed that the gel can be easily removed by reversing the gelation and washing it away with a cold irrigation solution. The impact on wound healing of the regular application and removal of PIC dressings is compared to a single application of PIC and the clinically used Tegaderm™ in murine splinted full-thickness wounds for up to 14 days. SPECT/CT analysis of <sup>111</sup>In-labelled PIC gels showed that, on average, 58% of the PIC gel could be washed out of the wounds with the employed method, which is, however, heavily influenced by personal technique. Evaluation with photography and (immuno-)histology showed that wounds in which PIC dressings were regularly removed and replaced were smaller at 14 days post-injury but performed on par with the control treatment. Moreover, the encapsulation of PIC in wound tissue was less severe and occurred less often when PIC was regularly refreshed. In addition, no morphological damage related to the removal procedure was observed. Thus, PIC gels are atraumatic and perform similarly to currently employed wound dressing materials, offering possible future benefits for both clinicians and patients.https://www.mdpi.com/1422-0067/24/6/5127polyisocyanopeptidehydrogel wound dressing |
| spellingShingle | Roel C. Op ‘t Veld Lieke Joosten Peter Laverman Ewald M. Bronkhorst John A. Jansen X. Frank Walboomers Frank A. D. T. G. Wagener Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model International Journal of Molecular Sciences polyisocyanopeptide hydrogel wound dressing |
| title | Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model |
| title_full | Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model |
| title_fullStr | Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model |
| title_full_unstemmed | Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model |
| title_short | Repeated Application and Removal of Polyisocyanopeptide Hydrogel Wound Dressings in a Splinted Full-Thickness Wound Model |
| title_sort | repeated application and removal of polyisocyanopeptide hydrogel wound dressings in a splinted full thickness wound model |
| topic | polyisocyanopeptide hydrogel wound dressing |
| url | https://www.mdpi.com/1422-0067/24/6/5127 |
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