Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD
Abstract Aims Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver disease (MAFLD), while longitudinal data are scarce. We aimed to explore the impact of changes in relative skeletal muscle mass on the MAFLD treatment response. Metho...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Skeletal Muscle |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13395-023-00333-z |
| _version_ | 1797376709804163072 |
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| author | Ting Zhou Junzhao Ye Ling Luo Wei Wang Shiting Feng Zhi Dong Shuyu Zhuo Bihui Zhong |
| author_facet | Ting Zhou Junzhao Ye Ling Luo Wei Wang Shiting Feng Zhi Dong Shuyu Zhuo Bihui Zhong |
| author_sort | Ting Zhou |
| collection | DOAJ |
| description | Abstract Aims Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver disease (MAFLD), while longitudinal data are scarce. We aimed to explore the impact of changes in relative skeletal muscle mass on the MAFLD treatment response. Methods MAFLD patients undergoing magnetic resonance imaging-based proton density fat fraction for liver fat content (LFC) assessments and bioelectrical impedance analysis before and after treatment (orlistat, meal replacement, lifestyle modifications) were enrolled. Appendicular muscle mass (ASM) was adjusted by weight (ASM/W). Results Overall, 256 participants were recruited and divided into two groups: with an ASM/W increase (n=166) and without an ASM/W increase (n=90). There was a great reduction in LFC in the group with an ASM/W increase (16.9% versus 8.2%, P < 0.001). However, the change in LFC in the group without an ASM/W increase showed no significant difference (12.5% versus 15.0%, P > 0.05). △ASM/W Follow-up-Baseline [odds ratio (OR)=1.48, 95% confidence interval (CI) 1.05-2.07, P = 0.024] and △total fat mass (OR=1.45, 95% CI 1.12-1.87, P = 0.004) were independent predictors for steatosis improvement (relative reduction of LFC ≥ 30%). The subgroup analysis showed that, despite without weight loss, decrease in HOMA-IR (OR=6.21, 95% CI 1.28-30.13, P=0.023), △total fat mass Baseline -Follow-up (OR=3.48, 95% CI 1.95-6.21, P <0.001 and △ASM/W Follow-up-Baseline (OR=2.13, 95% CI 1.12-4.05, P=0.022) independently predicted steatosis improvement. Conclusions ASM/W increase and loss of total fat mass benefit the resolution of liver steatosis, independent of weight loss for MAFLD. |
| first_indexed | 2024-03-08T19:42:38Z |
| format | Article |
| id | doaj.art-87af9e068e7d4ac08e21ed9ccfef156f |
| institution | Directory Open Access Journal |
| issn | 2044-5040 |
| language | English |
| last_indexed | 2024-03-08T19:42:38Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Skeletal Muscle |
| spelling | doaj.art-87af9e068e7d4ac08e21ed9ccfef156f2023-12-24T12:32:30ZengBMCSkeletal Muscle2044-50402023-12-0113111410.1186/s13395-023-00333-zRestoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLDTing Zhou0Junzhao Ye1Ling Luo2Wei Wang3Shiting Feng4Zhi Dong5Shuyu Zhuo6Bihui Zhong7Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Radiology, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Nutrition, The First Affiliated Hospital, Sun Yat-sen UniversityDepartment of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen UniversityAbstract Aims Cross-sectional studies have demonstrated the association of skeletal muscle mass with metabolic-associated fatty liver disease (MAFLD), while longitudinal data are scarce. We aimed to explore the impact of changes in relative skeletal muscle mass on the MAFLD treatment response. Methods MAFLD patients undergoing magnetic resonance imaging-based proton density fat fraction for liver fat content (LFC) assessments and bioelectrical impedance analysis before and after treatment (orlistat, meal replacement, lifestyle modifications) were enrolled. Appendicular muscle mass (ASM) was adjusted by weight (ASM/W). Results Overall, 256 participants were recruited and divided into two groups: with an ASM/W increase (n=166) and without an ASM/W increase (n=90). There was a great reduction in LFC in the group with an ASM/W increase (16.9% versus 8.2%, P < 0.001). However, the change in LFC in the group without an ASM/W increase showed no significant difference (12.5% versus 15.0%, P > 0.05). △ASM/W Follow-up-Baseline [odds ratio (OR)=1.48, 95% confidence interval (CI) 1.05-2.07, P = 0.024] and △total fat mass (OR=1.45, 95% CI 1.12-1.87, P = 0.004) were independent predictors for steatosis improvement (relative reduction of LFC ≥ 30%). The subgroup analysis showed that, despite without weight loss, decrease in HOMA-IR (OR=6.21, 95% CI 1.28-30.13, P=0.023), △total fat mass Baseline -Follow-up (OR=3.48, 95% CI 1.95-6.21, P <0.001 and △ASM/W Follow-up-Baseline (OR=2.13, 95% CI 1.12-4.05, P=0.022) independently predicted steatosis improvement. Conclusions ASM/W increase and loss of total fat mass benefit the resolution of liver steatosis, independent of weight loss for MAFLD.https://doi.org/10.1186/s13395-023-00333-zMetabolic associated fatty liver diseaseRelative skeletal muscle massTreatment responseLiver fat contentWeight loss |
| spellingShingle | Ting Zhou Junzhao Ye Ling Luo Wei Wang Shiting Feng Zhi Dong Shuyu Zhuo Bihui Zhong Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD Skeletal Muscle Metabolic associated fatty liver disease Relative skeletal muscle mass Treatment response Liver fat content Weight loss |
| title | Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD |
| title_full | Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD |
| title_fullStr | Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD |
| title_full_unstemmed | Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD |
| title_short | Restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in MAFLD |
| title_sort | restoring skeletal muscle mass as an independent determinant of liver fat deposition improvement in mafld |
| topic | Metabolic associated fatty liver disease Relative skeletal muscle mass Treatment response Liver fat content Weight loss |
| url | https://doi.org/10.1186/s13395-023-00333-z |
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